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1897-45-6

1897-45-6 structure
1897-45-6 structure
  • Name: Chlorothalonil
  • Chemical Name: chlorothalonil
  • CAS Number: 1897-45-6
  • Molecular Formula: C8Cl4N2
  • Molecular Weight: 265.911
  • Catalog: Chemical pesticide Fungicide Substituted benzene fungicide
  • Create Date: 2018-03-16 08:00:00
  • Modify Date: 2024-01-02 12:08:09
  • Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops[1][2].
Name chlorothalonil
Synonyms meta-TCPN
2,4,5,6-Tetrachloroisophthalonitrile
Chloroalonil
MFCD00045594
2,4-Dicyanotetrachlorobenzene
1,3-dicyano-2,4,5,6-tetrachlorobenzene
2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile
2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile
m-Tcpn
2,4,5,6-tetrachloro-1,3-dicyanobenzene
Nopcocide
TPN
Perchloroisophthalonitrile
2,4,5,6-tetrachloroisophthalodinitrile
Chlorothalonil
EINECS 217-588-1
tetrachloroisophthalonitrile
Bravo
Daconil
1,3-Benzenedicarbonitrile, 2,4,5,6-tetrachloro-
Tetrachloroisophthalodinitrile
1,3-dicyanotetrachlorobenzene
Description Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops[1][2].
Related Catalog
References

[1]. Pengfei Zhang, et al. Low Dose Chlorothalonil Impairs Mouse Spermatogenesis Through the Intertwining of Estrogen Receptor Pathways With Histone and DNA Methylation.Chemosphere. 2019 Sep;230:384-395.

[2]. Małgorzata Baćmaga, et al. The Influence of Chlorothalonil on the Activity of Soil Microorganisms and Enzymes. Ecotoxicology. 2018 Nov;27(9):1188-1202.
Density 1.7±0.1 g/cm3
Boiling Point 350.5±37.0 °C at 760 mmHg
Melting Point 250-251ºC
Molecular Formula C8Cl4N2
Molecular Weight 265.911
Flash Point 153.8±20.7 °C
Exact Mass 263.881561
PSA 47.58000
LogP 2.88
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.633

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NT2600000
CHEMICAL NAME :
Isophthalonitrile, tetrachloro-
CAS REGISTRY NUMBER :
1897-45-6
LAST UPDATED :
199710
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
C8-Cl4-N2
MOLECULAR WEIGHT :
265.90
WISWESSER LINE NOTATION :
NCR BG CG DG FG ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
310 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6750 mg/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
142 gm/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TEST SYSTEM :
Fish - not otherwise specified
DOSE/DURATION :
1400 ppt/7D (Continuous)
REFERENCE :
HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 12,153,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,319,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1833 No. of Facilities: 3268 (estimated) No. of Industries: 21 No. of Occupations: 26 No. of Employees: 62724 (estimated) No. of Female Employees: 6716 (estimated)
Symbol GHS05 GHS06 GHS08 GHS09
GHS05, GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H317-H318-H330-H335-H351-H410
Precautionary Statements P260-P273-P280-P284-P304 + P340 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T+;N
Risk Phrases R26;R37;R40;R41;R43;R50/53
Safety Phrases S28-S36/37/39-S45-S60-S61-S36/37-S26
RIDADR 3276
RTECS NT2600000
Packaging Group I
Hazard Class 6.1(a)
HS Code 2926909090
HS Code 2926909038
Summary HS: 2926909038 fenoxanil Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:S(Registration certificate of import and export) Lowest tariff:6.5% General tariff:30.0%

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