88546-74-1

88546-74-1 structure

Name: H-D-Pro-Phe-Arg-chloromethylketone trifluoroacetate salt
Chemical Name: (2R)-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
CAS Number: 88546-74-1
Molecular Formula: C₂₁H₃₁ClN₆O₃
Molecular Weight: 450.96200
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2018-10-12 17:43:45
Modify Date: 2025-08-25 23:13:49
D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1].

Name	(2R)-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
Synonyms	D-Pro-Phe-Arg chloromethyl ketone D-Pro-Phe-Arg chloromethyl ketone (PCK) L-Phenylalaninamide,D-prolyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-,(S) H-D-Pro-Phe-Arg-chloromethylketone

Description	D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
References	[1]. Katrin F Nickel, et al. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20.