CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KG5792000
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CHEMICAL NAME :
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Estradiol, polyester with phosphoric acid
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CAS REGISTRY NUMBER :
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28014-46-2
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LAST UPDATED :
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199512
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DATA ITEMS CITED :
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5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 15,56,1980
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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6100 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 15,56,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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39 gm/kg/26W-I
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TOXIC EFFECTS :
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Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 15,56,1980 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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173 mg/kg/9Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
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REFERENCE :
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ACLRBL Annals of Clinical Research. (Finnish Medical Soc., Duodecim, Runeberginkatu 47A, SF-00260 Helsinki 26, Finland) V.1- 1969- Volume(issue)/page/year: 7,287,1975 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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DOSE :
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50 mg/kg
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SEX/DURATION :
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female 19 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - urogenital system
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REFERENCE :
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ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 33,520,1960
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