53267-01-9

53267-01-9 structure

Name: Cibenzoline
Chemical Name: Cibenzoline
CAS Number: 53267-01-9
Molecular Formula: C₁₈H₁₈N₂
Molecular Weight: 262.34900
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-09-10 14:16:17
Modify Date: 2024-01-02 23:04:11
Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].

Name	Cibenzoline
Synonyms	Cibenzolinum [inn-latin] UP 33-901 Cibenzolinum Exacor 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole Cibenzolina Cibenol 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1 H-imidazole Ro 22-7796 [15N]-Cibenzoline Cifenline

Description	Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	KATP channel[1]
References	[1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481. [2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524.

HS Code	2933290090

28098-84-2

107-15-3

~85%

53267-01-9

Literature: Gholap, Atul R.; Paul, Vincent; Srinivasan, Kumar V. Synthetic Communications, 2008 , vol. 38, # 17 p. 2967 - 2982

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%