Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ecabet sodium
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ecabet sodium
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DC Chemicals Limited
China
Product Name: Ecabet (sodium salt)
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Ecabet (sodium salt)
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ecabet sodium
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86408-72-2

86408-72-2 structure

86408-72-2 structure

Name: Ecabet sodium
Chemical Name: Ecabet sodium
CAS Number: 86408-72-2
Molecular Formula: C₂₀H₂₇NaO₅S
Molecular Weight: 402.480
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-02-14 08:00:00
Modify Date: 2024-01-02 11:35:39
Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2].

Name	Ecabet sodium
Synonyms	12-sulfodehydroabietic acid 12-sodium salt pentahydrate Ecabetsodiumsalt Sodium 18-hydroxy-18-oxoabieta-8(14),9(11),12-triene-12-sulfonate 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, sodium salt, (1R,4aS,10aR)- (1:1) 1-Phenanthrenecarboxylic acid,1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,monosodium salt,(1R,4aS,10aR) Gastrom 12-Sulfodehydroabietic acid monosodium salt ta-2711

Description	Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	ROS production; Bacterial[1]; Apoptosis[2]
References	[1]. Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81. [2]. Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83.

Density	1.241 g/cm3
Molecular Formula	C₂₀H₂₇NaO₅S
Molecular Weight	402.480
Exact Mass	402.147675
PSA	102.88000
LogP	4.88980
Index of Refraction	1.562

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF7312000

CHEMICAL NAME :: 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-meth ylethyl)- 6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt

CAS REGISTRY NUMBER :: 86408-72-2

LAST UPDATED :: 199603

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H28-O5-S.Na

MOLECULAR WEIGHT :: 403.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4529602 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11 gm/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,941,1991

Hazard Codes	Xi

86408-71-1 structure

86408-71-1

~88%

86408-72-2 structure

86408-72-2

Literature: Wada; Kodato; Kawamori; Morikawa; Nakai; Takeda; Saito; Onoda; Tamaki Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1472 - 1487

Precursor 1
86408-71-1
DownStream 0