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86408-72-2

86408-72-2 structure
86408-72-2 structure
  • Name: Ecabet sodium
  • Chemical Name: Ecabet sodium
  • CAS Number: 86408-72-2
  • Molecular Formula: C20H27NaO5S
  • Molecular Weight: 402.480
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-02-14 08:00:00
  • Modify Date: 2024-01-02 11:35:39
  • Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2].
Name Ecabet sodium
Synonyms 12-sulfodehydroabietic acid 12-sodium salt pentahydrate
Ecabetsodiumsalt
Sodium 18-hydroxy-18-oxoabieta-8(14),9(11),12-triene-12-sulfonate
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, sodium salt, (1R,4aS,10aR)- (1:1)
1-Phenanthrenecarboxylic acid,1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,monosodium salt,(1R,4aS,10aR)
Gastrom
12-Sulfodehydroabietic acid monosodium salt
ta-2711
Description Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2].
Related Catalog
Target

ROS production; Bacterial[1]; Apoptosis[2]
References

[1]. Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81.

[2]. Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83.
Density 1.241 g/cm3
Molecular Formula C20H27NaO5S
Molecular Weight 402.480
Exact Mass 402.147675
PSA 102.88000
LogP 4.88980
Index of Refraction 1.562

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SF7312000
CHEMICAL NAME :
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-meth ylethyl)- 6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt
CAS REGISTRY NUMBER :
86408-72-2
LAST UPDATED :
199603
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H28-O5-S.Na
MOLECULAR WEIGHT :
403.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4529602 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11 gm/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,941,1991
Hazard Codes Xi
86408-71-1 structure

86408-71-1

~88%

86408-72-2 structure

86408-72-2
Literature: Wada; Kodato; Kawamori; Morikawa; Nakai; Takeda; Saito; Onoda; Tamaki Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 4 p. 1472 - 1487
Precursor  1

DownStream  0


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