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303-26-4

303-26-4 structure
303-26-4 structure
Name 1-(4-Chlorobenzhydryl)piperazine
Synonyms Levocetrizine IMpurity A
N-(4-CHLOROBENZHYDRYL)-PIPERAZINE
Hydroxyzine Impurity 1(Hydroxyzine Impurity A)
Hydroxyzine Related Compound A
N-(4-CHLOROBENZYLHYDRYL)PIPERAZINE
Meclozine impurity H CRS
1-[(4-Chlorophenyl)(phenyl)methyl]piperazine
Cetirizine Impurity A
1-(alpha-Phenyl-4-chlorobenzyl)piperazine
1-(p-chlorobenzhydryl)piperazine
N-[(4-chlorophenyl)phenylmethyl]piperazine
1-(4-chlorobenzhydryl)
TIMTEC-BB SBB002998
1-(4-Chlorobenzhydryl)piperazine >
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]
N-(P-CHLOROBENZHYDRYL)-PIPERAZINE
4-(4-Chlorobenzhydryl)piperazine
Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)
(1-(p-Chloro- -phenylbenzyl)-piperazine
Buclizine HCl IMpurity (BP
1-(4-Chlorobenzhydryl)-piperizine
1-(-Chlorobenzhdryl) piperazine
Cetirizine Dihydrochloride impurity A
4-(Chlorobenzhydryl)Piperazine(Purified)Hydroxyzine/Cetirizine
1-((4-chlorophenyl)phenylmethyl)-piperazin
Cetirizine Impurity 9（Cetirizine Impurity A）
Buclizine Impurity 1
(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
Cetirizine IMpurity-A/BP)
1-(4-Chloro-a-phenylbenzyl)piperazine
Piperazine, 1-(p-chloro-alpha-phenylbenzyl)
1-(4-CHLORODIPHENYLMETHYL)-PIPERAZINE
1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE
Hydroxyzine Related CoMpound A
EINECS 206-137-4
Hydroxyzine Impurity A
(RS)-1-[(4-Chlorophenyl)phenylmethy
Hydroxyzine Related Compound A (25 mg) (p-Chlorobenzhydrylpiperazine)
Cetirizine impurity A CRS
4-CHLORO BENZHYDRYL PIPERAZINE ( PA CHLORO BENZHYDRYL PIPERAZINE ) ( INTERMEDIATE FOR CETIRIZINE HCL E. P. / B. P. )
1-(4-Chloro-alpha-phenylbenzyl)piperazine
4-(α-Piperazinobenzyl)phenyl chloride
Norchlorcyclizine
1-((4-Chlorophenyl)(phenyl)methyl)piperazine
1-(4-CHLOROBENZHYDRYL)PIPERAZINE
1-(4-chlorobenzhydryl)-piperazine
Meclozine impurity H
Meclizine Impurity H
Cetirizine Impurity 13
N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine
Cetirizine -Imp-A
1-(4-Chlorobenzhydryl)piperazine ade
1-(p-chloro-alpha-phenylbenzyl)-piperazin
1-(4-CHLOROPHENYLMETHYL)PIPERAZINE
Piperazine, 1-(alpha-(4-chloropheny
1-(α-Phenyl-4-chlorobenzyl)piperazine
1-(4-Chlorobenzhydry)piperazine
1-(p-chloro-alpha-phenylbenzyl)-piperazine
1-(4-Chlorobenzhydryl) piperazine
1-(4-Chloro-α-phenylbenzyl)piperazine
1-(4-Chlorobenzhydryl)piperazine, R
1-(p-Chloro-a-phenylbenzyl)-piperazine
1-(4-Chlorodiphenylmethyl)piperazine
1-[(4-CHLORO-PHENYL)-PHENYL-METHYL]-PIPERAZINE
MFCD00005965
1-[(4-chlorophenyl)phenylmethyl]-piperazine
N-(4-Chlorophenyl)phenylmethylpiperazine
Description 1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog
In Vitro 1-(4-氯苄基)哌嗪是美氯嗪和氯环嗪的无活性代谢物，在羟嗪和西替利嗪的商业制剂中也发现它是一种杂质。1-(4-氯苄基)哌嗪已被用于合成电压门控钠通道 1.7 (Nav1.7) 抑制剂、抗癌剂和抗组胺剂。
References

[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973)

[2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965)

[3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996)

[4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014)

[5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015)

[6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012)

[7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Density 1.2±0.1 g/cm3
Boiling Point 409.1±0.0 °C at 760 mmHg
Melting Point 65-70 °C(lit.)
Molecular Formula C17H19ClN2
Molecular Weight 286.80
Flash Point 193.3±26.5 °C
Exact Mass 286.123688
PSA 15.27000
LogP 3.44
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.592
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL1772000
CHEMICAL NAME :
Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-
CAS REGISTRY NUMBER :
303-26-4
BEILSTEIN REFERENCE NO. :
0243027
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H19-Cl-N2
MOLECULAR WEIGHT :
286.83
WISWESSER LINE NOTATION :
T6M DNTJ DYR&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 12-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TL1772000
HS Code 2933599090
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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