51116-01-9

51116-01-9 structure

Name: 8-Br-cGMP(8-Bromo-cGMP)
Chemical Name: 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
CAS Number: 51116-01-9
Molecular Formula: C₁₀H₁₀BrN₅NaO₇P
Molecular Weight: 446.083
Create Date: 2018-05-29 08:00:00
Modify Date: 2024-01-14 18:14:25
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2].

Name	8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
Synonyms	8-Br-cGMP 8-Bromo-cyclic GMP EINECS 256-993-8 sodium 8-bromo-3',5'-cyclic GMP Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide 8-Bromo-cGMP, sodium salt,8-Bromoguanosinecyclic3',5'-monophosphatesodiumsalt 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1) MFCD00070128

Description	8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2].
Target	PKG, Ca2+[1]
References	[1]. Sarkar O , et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301. [2]. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50.

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