8-Br-cGMP(8-Bromo-cGMP)
8-Br-cGMP(8-Bromo-cGMP) structure
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Common Name | 8-Br-cGMP(8-Bromo-cGMP) | ||
|---|---|---|---|---|
| CAS Number | 51116-01-9 | Molecular Weight | 446.083 | |
| Density | 2.96 g/cm3 | Boiling Point | 794.3ºC at 760 mmHg | |
| Molecular Formula | C10H10BrN5NaO7P | Melting Point | N/A | |
| MSDS | USA | Flash Point | 434.2ºC | |
Use of 8-Br-cGMP(8-Bromo-cGMP)8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2]. |
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| Target |
PKG, Ca2+[1] |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 2.96 g/cm3 |
|---|---|
| Boiling Point | 794.3ºC at 760 mmHg |
| Molecular Formula | C10H10BrN5NaO7P |
| Molecular Weight | 446.083 |
| Flash Point | 434.2ºC |
| Exact Mass | 444.939880 |
| PSA | 187.45000 |
| LogP | 0.25780 |
| InChIKey | FJAOOACZDYDVJT-YEOHUATISA-N |
| SMILES | Nc1nc2c(nc(Br)n2C2OC3COP(=O)(O)OC3C2O)c(=O)[nH]1.[Na] |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.
PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c... |
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Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.
Br. J. Pharmacol. 171(24) , 5858-69, (2014) Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadi... |
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Platelet-derived HMGB1 is a critical mediator of thrombosis.
J. Clin. Invest. 125 , 4638-54, (2015) Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular patt... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 8-Br-cGMP 8-Bromo-cyclic GMP |
| EINECS 256-993-8 |
| sodium 8-bromo-3',5'-cyclic GMP |
| Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide |
| 8-Bromo-cGMP, sodium salt,8-Bromoguanosinecyclic3',5'-monophosphatesodiumsalt |
| 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1) |
| MFCD00070128 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: Molecular formula of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is C10H10BrN5NaO7P. |
| Q: What is the polar surface area (PSA) of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: Polar surface area (PSA) of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is 187.45000. |
| Q: What is the SMILES notation of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: SMILES notation of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is Nc1nc2c(nc(Br)n2C2OC3COP(=O)(O)OC3C2O)c(=O)[nH]1.[Na]. |
| Q: What is the LogP of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: LogP of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is 0.25780. |
| Q: What is the English name of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: The English name of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt. |
| Q: What is the CAS number of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: CAS number of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is 51116-01-9. |
| Q: What is the molecular weight of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: Molecular weight of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is 446.083. |
| Q: What is the InChIKey of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: InChIKey of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is FJAOOACZDYDVJT-YEOHUATISA-N. |
| Q: What are the uses of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: Main uses of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt: 8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2]. |
| Q: What is the boiling point of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt? |
| A: Boiling point of 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt is 794.3ºC at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |