630-60-4
630-60-4 structure
- Name: g-Strophanthin
- Chemical Name: ouabain
- CAS Number: 630-60-4
- Molecular Formula: C29H44O12
- Molecular Weight: 584.65200
- Catalog: API Circulatory system medication Anti-congestive heart failure medicine
- Create Date: 2018-04-19 08:00:00
- Modify Date: 2024-01-03 11:41:58
| Name | ouabain |
|---|---|
| Synonyms |
uabaina
Ouabain,3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide ASTROBAIN oubain OUABAIN GRATIBAIN QUABAIN strodival EINECS 211-139-3 uabanin g-strophanthin MFCD00003688 |
| Density | 1.1941 (rough estimate) |
|---|---|
| Boiling Point | 561.69°C (rough estimate) |
| Melting Point | 200°C |
| Molecular Formula | C29H44O12 |
| Molecular Weight | 584.65200 |
| Exact Mass | 584.28300 |
| PSA | 206.60000 |
| Appearance | powder | white |
| Index of Refraction | -32 ° (C=1, H2O) |
| Storage condition | Desiccate at -20°C |
| Water Solubility | H2O: 10 mg/mL cold |
|
Section I.Chemical Product and Company Identification Chemical Name g-Strophanthin Portland OR Ouabain Synonym C29H44O12•8H2O Chemical Formula
CAS Number630-60-4 Section II.Composition and Information on Ingredients Chemical NameCAS Number Percent (%)TLV/PELToxicology Data g-Strophanthin630-60-4---------- Not available.Rat LD50 (intravenous) 14 mg/kg Mouse LD50 (oral) 5 mg/kg Mouse LD50 (intraperitoneal) 11 mg/kg Mouse LD50 (subcutaneous) 5 mg/kg Section III. Hazards Identification Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or Acute Health Effects death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Chronic Health EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Section IV.First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Skin ContactIn case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or Inhalation waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not improve. INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. Ingestion Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Section V.Fire and Explosion Data Not available. FlammabilityMay be combustible at high temperature.Auto-Ignition Flammable Limits Flash PointsNot available.Not available. Combustion ProductsThese products are toxic carbon oxides (CO, CO2). Fire Hazards Not available. Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. and Instructions Consult with local fire authorities before attempting large scale fire-fighting operations. Continued on Next Page g-Strophanthin Section VI.Accidental Release Measures Spill CleanupHighly Toxic material. Light sensitive material. Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce Instructions vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition. Consult federal, state, and/or local authorities for assistance on disposal. Section VII. Handling and Storage Handling and StorageHIGHLY TOXIC. LIGHT SENSITIVE. Keep locked up. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. DO NOT ingest. Do not Information breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Treat symptomatically and supportively. Always store away from incompatible compounds such as oxidizing agents, acids, alkalis (bases). Section VIII. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section IX. Physical and Chemical Properties Solubility Physical state @ 20°CSolid. (White, Crystalline powder.)Not available. Not available. Specific Gravity Molecular Weight584.65 (Anh)Partition CoefficientNot available. Boiling PointNot available.Vapor PressureNot applicable. Melting PointNot available.Vapor DensityNot available. Not available.VolatilityNot available. Refractive Index Critical TemperatureNot available.OdorNot available. Not available.Not available. ViscosityTaste Section X.Stability and Reactivity Data This material is stable if stored under proper conditions. (See Section VII for instructions) Stability Conditions of InstabilityAvoid excessive heat and light. Incompatibilities Reactive with strong oxidizing agents, strong acids, strong alkalis (bases). Section XI. Toxicological Information RTECS NumberRN3850000 Eye Contact. Ingestion. Inhalation. Routes of Exposure Rat LD50 (intravenous) 14 mg/kg Toxicity Data Mouse LD50 (oral) 5 mg/kg Mouse LD50 (intraperitoneal) 11 mg/kg Mouse LD50 (subcutaneous) 5 mg/kg Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or Acute Toxic Effects death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Continued on Next Page g-Strophanthin Section XII.Ecological Information EcotoxicityNot available. Not available. Environmental Fate Section XIII. Disposal Considerations Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a Waste Disposal combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section XIV. Transport Information DOT ClassificationDOT CLASS 6.1: Toxic material. PIN Number Proper Shipping Name Alkaloids, solid, n.o.s. Packing Group (PG)II DOT Pictograms Section XV. Other Regulatory Information and Pictograms TSCA Chemical InventoryThis compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list. (EPA) WHMIS ClassificationOn NDSL (Canada) EINECS Number (EEC) 211-139-3 EEC Risk StatementsR23/24/25- Toxic by inhalation, in contact with skin and if swallowed. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Hazard Codes | T |
|---|---|
| Risk Phrases | 23/25-33 |
| Safety Phrases | 45 |
| RIDADR | UN 1544 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | RN3850000 |
|
~88%
630-60-4 |
| Literature: Zhang, Hongxing; Sridhar Reddy, Maddi; Phoenix, Serge; Deslongchamps, Pierre Angewandte Chemie - International Edition, 2008 , vol. 47, # 7 p. 1272 - 1275 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
