71160-24-2

71160-24-2 structure

Name: Leukotriene B4
Chemical Name: leukotriene B4
CAS Number: 71160-24-2
Molecular Formula: C₂₀H₃₂O₄
Molecular Weight: 336.466
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-08-07 11:07:06
Modify Date: 2024-01-03 01:03:42
Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	leukotriene B4
Synonyms	(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid Leukotriene B4 6Z,8E,10E,14Z,5S,12R-diHETE (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid EINECS 200-578-6 LTB4 Leukotriene B4,(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoicacid Leukotriene B4 Lipid Maps MS Standard MFCD00135630 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-

Description	Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain Human Endogenous Metabolite
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562