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  • Product Name: BQ-123
  • Price: $1500.0/100mg $2500.0/250mg $5000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
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136553-81-6

136553-81-6 structure
136553-81-6 structure
  • Name: BQ-123
  • Chemical Name: bq-123
  • CAS Number: 136553-81-6
  • Molecular Formula: C31H42N6O7
  • Molecular Weight: 610.701
  • Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
  • Create Date: 2019-02-16 11:23:26
  • Modify Date: 2024-01-13 10:58:03
  • BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
Name bq-123
Synonyms Cyclo(L-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
d-trp-d-asp-pro-d-val-leu
bq-518
MFCD00133204
BQ-123
m.w. 610.70 c31h42n6o7
Description BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
Related Catalog
References

[1]. Olgun NS et al. BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicol Appl Pharmacol, 2015 Feb 1;282(3):275-84.

[2]. Kanashiro A et al. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Res, 2015 Jun 12, 1610:12-9.

[3]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.
Density 1.3±0.1 g/cm3
Boiling Point 1053.6±65.0 °C at 760 mmHg
Molecular Formula C31H42N6O7
Molecular Weight 610.701
Flash Point 591.0±34.3 °C
Exact Mass 610.311523
PSA 189.80000
LogP -0.10
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.621
Storage condition -20℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport

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title: CAS No. 136553-81-6 | Chemsrc address: https://m.chemsrc.com/en/baike/753825.html

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