136553-81-6
136553-81-6 structure
- Name: BQ-123
- Chemical Name: bq-123
- CAS Number: 136553-81-6
- Molecular Formula: C31H42N6O7
- Molecular Weight: 610.701
- Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
- Create Date: 2019-02-16 11:23:26
- Modify Date: 2024-01-13 10:58:03
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BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
| Name | bq-123 |
|---|---|
| Synonyms |
Cyclo(L-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
d-trp-d-asp-pro-d-val-leu bq-518 MFCD00133204 BQ-123 m.w. 610.70 c31h42n6o7 |
| Description | BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1053.6±65.0 °C at 760 mmHg |
| Molecular Formula | C31H42N6O7 |
| Molecular Weight | 610.701 |
| Flash Point | 591.0±34.3 °C |
| Exact Mass | 610.311523 |
| PSA | 189.80000 |
| LogP | -0.10 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.621 |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| Precursor 4 | |
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| DownStream 0 | |