136553-81-6

136553-81-6 structure

Name: BQ-123
Chemical Name: bq-123
CAS Number: 136553-81-6
Molecular Formula: C₃₁H₄₂N₆O₇
Molecular Weight: 610.701
Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
Create Date: 2019-02-16 11:23:26
Modify Date: 2026-07-09 17:32:36
BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.

Name	bq-123
Synonyms	CYCLO(D-ASP-PRO-D-VAL-LEU-D-TRP) Cyclo(D-Trp-D-Asp-L-Pro-D-Val-L-Leu-) BQ-123, ETA rector antagonist inhibit,blood,Endothelin Rector,tery,BQ-123,pressure,muscle,smooth,cells,BQ 123,Inhibitor,pulmony CYCLO(-D-TRP-D-ASP-PRO-D-VAL-LEU) BQ-123;BQ 123;BQ BQ-123 SYNTHETIC SELECTIVE ETA ENDO THE Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-) Cyclo(L-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl) ETA-Rector Antagonist [BQ-123] sodium salt Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-] BQ-123 >=, sodium salt, lyophilized powder ONIST bq-518 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid C(DTRP-DASP-PRO-DVAL-LEU) D-TRP-D-ASP-PRO-D-VAL-LEU C31H42N6O7 BQ-123 SODIUM SALT CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT ETA-RECTOR ANTAGONIST Cyclo(D-α-asptyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl d-trp-d-asp-pro-d-val-leu 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA) BQ-518 CYCLO (D-ALPHA-ASPTYL-L-PROLYL-D-VALYL-L-LEUCYL-D-TRYPTOPHYL) BQ-123, 10 mM in DMSO Cyclo(D-α-asptyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl) cyclo(Trp-Asp-Pro-Val-Leu) MFCD00133204 136-6 BQ-123 SODIUM SALT m.w. 610.70 c31h42n6o7

Description	BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model.2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10.3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Infection
References	[1]. Olgun NS et al. BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. Toxicol Appl Pharmacol, 2015 Feb 1;282(3):275-84. [2]. Kanashiro A et al. Cytokines, but not corticotropin-releasing factor and endothelin-1, participate centrally in the febrile response in zymosan-induced arthritis in rats. Brain Res, 2015 Jun 12, 1610:12-9. [3]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

160195-16-4

~65%

136553-81-6

166760-86-7

136553-81-6

Literature: Journal of Medicinal Chemistry, , vol. 38, # 21 p. 4309 - 4324

13139-15-6

22838-58-0

5241-64-5

214630-04-3

Detail

Literature: Journal of Medicinal Chemistry, , vol. 39, # 19 p. 3842 - 3846

Precursor 4
13139-15-6 22838-58-0 5241-64-5 214630-04-3
DownStream 0