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73220-03-8

73220-03-8 structure
73220-03-8 structure
  • Name: Remoxipride hydrochloride
  • Chemical Name: Remoxipride hydrochloride,(S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamidehydrochloride
  • CAS Number: 73220-03-8
  • Molecular Formula: C16H24BrClN2O3
  • Molecular Weight: 407.73
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2018-07-09 17:09:19
  • Modify Date: 2024-01-14 15:21:32
  • (S)-Remoxipride ((-)-Remoxipride) hydrochloride is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride hydrochloride can be used for the research of psychotic disorder[1].

Name Remoxipride hydrochloride,(S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamidehydrochloride
Synonyms Macbecin I
REMOXIPRIDE HYDROCHLORIDE
Description (S)-Remoxipride ((-)-Remoxipride) hydrochloride is a selective dopamine D2-receptor antagonist with an IC50 value of 1.57 μM. (S)-Remoxipride hydrochloride can be used for the research of psychotic disorder[1].
Related Catalog
In Vitro (S)-Remoxipride hydrochloride (1-100 μM; 20 min) shows binding efficiency with IC50s of >100, 1.57 and 42 μM for dopamine D1, dopamine D2 and α1-Adrenoccptor, respectively[1].
In Vivo (S)-Remoxipride hydrochloride (0.1-100 μM/kg; i.p. 60 min prior to apomorphine) blockades apomorphine-induced behaviors s in rats and vomiting in dogs[1]. (S)-Remoxipride hydrochloride (0.1-10 mg/kg; i.p. 30 min prior to apomorphine) displaces [3H]spiperone from both striatal and extra-striatal areas[1].
References

[1]. Ogren SO, et al. Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain. Eur J Pharmacol. 1984 Jul 20;102(3-4):459-74.  

Molecular Formula C16H24BrClN2O3
Molecular Weight 407.73
Exact Mass 406.06600
PSA 50.80000
LogP 3.81120

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV2369000
CHEMICAL NAME :
Benzamide, 3-bromo-2,6-dimethoxy-N-(1-ethyl-2-pyrrolidinylmethyl )-, hydrochloride, (S)-(-)-
CAS REGISTRY NUMBER :
73220-03-8
LAST UPDATED :
199412
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H23-Br-N2-O3
MOLECULAR WEIGHT :
371.32
WISWESSER LINE NOTATION :
T5NTJ A2 B1MVR CE BO1 FO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
324 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,1280,1982
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%