183364-82-1

183364-82-1 structure

Name: CPPG
Chemical Name: CPPG,(RS)-α-Cyclopropyl-4-phosphonophenylglycine
CAS Number: 183364-82-1
Molecular Formula: C₁₁H₁₄NO₅P
Molecular Weight: 271.20600
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-07-27 01:35:15
Modify Date: 2025-08-25 10:36:53
CPPG ((RS)-CPPG) is a potent group II/III mGlu receptor antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

Name	CPPG,(RS)-α-Cyclopropyl-4-phosphonophenylglycine
Synonyms	CPPG Water,sterile filtered

Description	CPPG ((RS)-CPPG) is a potent group II/III mGlu receptor antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vitro	CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].
References	[1]. Toms NJ, et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119(5):851-4.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport