Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: BAPTA-AM
Price: ￥2598.0/25mg
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: BAPTA/AM(BAPTA-AM)
Price: $350.0/100mg $600.0/250mg $1300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

126150-97-8

126150-97-8 structure

126150-97-8 structure

Name: BAPTA-AM
Chemical Name: acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
CAS Number: 126150-97-8
Molecular Formula: C₃₄H₄₀N₂O₁₈
Molecular Weight: 764.684
Catalog: Biochemical Assay Reagents
Create Date: 2018-12-27 09:22:45
Modify Date: 2024-01-02 19:04:18
BAPTA-AM is an intracellular calcium chelator.

Name	acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
Synonyms	tetraacetoxymethyl ester Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid Tetrakis(acetoxymethyl) Ester MFCD00036696 Tetrakis(acetoxymethyl) 2,2',2'',2'''-[1,2-ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetate Tetrakis(acetoxymethyl) 2,2',2'',2'''-[ethane-1,2-diylbis(oxy-2,1-phenylenenitrilo)]tetraacetate BAPTA-acetoxymethylester BAPTA-AM

Description	BAPTA-AM is an intracellular calcium chelator.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Biochemical Assay Reagents
Target	calcium chelator[1]
In Vitro	The permeable calcium chelator BAPTA/AM is known to prevent free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA/AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10μM BAPTA/AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA/AM for 48-hr evoke dose-dependent neuronal damage[1].
Cell Assay	Neuronal injury is quantitatively estimated by measuring lactate dehydrogenase (LDH) released from damaged cells into the bathing medium 24- or 48-hr after the 10 μM BAPTA/AM treatment. The morphological findings are confirmed by staining with neuron-specific enolase (NSE) antibody and tryphan blue[1].
References	[1]. Wie MB, et al. BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov;25(8):1641-59.

Density	1.4±0.1 g/cm3
Boiling Point	796.1±60.0 °C at 760 mmHg
Melting Point	86-90°C
Molecular Formula	C₃₄H₄₀N₂O₁₈
Molecular Weight	764.684
Flash Point	435.3±32.9 °C
Exact Mass	764.227600
PSA	235.34000
LogP	2.28
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.551
Storage condition	−20°C
Stability	Light Sensitive

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3