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126150-97-8

126150-97-8 structure
126150-97-8 structure
  • Name: BAPTA-AM
  • Chemical Name: acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
  • CAS Number: 126150-97-8
  • Molecular Formula: C34H40N2O18
  • Molecular Weight: 764.684
  • Catalog: Biochemical Assay Reagents
  • Create Date: 2018-12-27 09:22:45
  • Modify Date: 2024-01-02 19:04:18
  • BAPTA-AM is an intracellular calcium chelator.
Name acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
Synonyms tetraacetoxymethyl ester
Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid Tetrakis(acetoxymethyl) Ester
MFCD00036696
Tetrakis(acetoxymethyl) 2,2',2'',2'''-[1,2-ethanediylbis(oxy-2,1-phenylenenitrilo)]tetraacetate
Tetrakis(acetoxymethyl) 2,2',2'',2'''-[ethane-1,2-diylbis(oxy-2,1-phenylenenitrilo)]tetraacetate
BAPTA-acetoxymethylester
BAPTA-AM
Description BAPTA-AM is an intracellular calcium chelator.
Related Catalog
Target

calcium chelator[1]

In Vitro The permeable calcium chelator BAPTA/AM is known to prevent free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA/AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10μM BAPTA/AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA/AM for 48-hr evoke dose-dependent neuronal damage[1].
Cell Assay Neuronal injury is quantitatively estimated by measuring lactate dehydrogenase (LDH) released from damaged cells into the bathing medium 24- or 48-hr after the 10 μM BAPTA/AM treatment. The morphological findings are confirmed by staining with neuron-specific enolase (NSE) antibody and tryphan blue[1].
References

[1]. Wie MB, et al. BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov;25(8):1641-59.
Density 1.4±0.1 g/cm3
Boiling Point 796.1±60.0 °C at 760 mmHg
Melting Point 86-90°C
Molecular Formula C34H40N2O18
Molecular Weight 764.684
Flash Point 435.3±32.9 °C
Exact Mass 764.227600
PSA 235.34000
LogP 2.28
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.551
Storage condition −20°C
Stability Light Sensitive
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3

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title: CAS No. 126150-97-8 | Chemsrc address: https://m.chemsrc.com/en/baike/753882.html

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