40709-69-1

40709-69-1 structure

Name: Bicuculline methiodide
Chemical Name: (-)-Bicuculline methiodide,[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinoliniumiodide
CAS Number: 40709-69-1
Molecular Formula: C₂₁H₂₀INO₆
Molecular Weight: 509.29
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2016-08-02 01:24:43
Modify Date: 2024-01-03 17:49:01
Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].

Name	(-)-Bicuculline methiodide,[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinoliniumiodide
Synonyms	bicuculine methiodide

Description	Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Bicuculline methiodide (30 μM) 促进 N-甲基-d-天冬氨酸 (NMDA) 刺激，促进多巴胺神经元的爆发性放电[1]。研究表明，反奖励中枢外侧缰核（LHb）的簇状放电是抑郁症发生的充分条件。LHb神经元常分为三类：沉默型（silent）, 强直放电型（tonic-firing），簇状放电型（burst-firing）[2]。
References	[1]. Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231(1):13-6. [2]. Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554(7692): 317-322.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

74-88-4

485-49-4

~99%

40709-69-1

Literature: Slavik, Jiri; Slavikova, Leonora Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 2009 - 2020

Precursor 2
74-88-4 485-49-4
DownStream 0