Bicuculline methiodide
Modify Date: 2024-01-03 17:49:01
Bicuculline methiodide structure
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Common Name | Bicuculline methiodide | ||
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| CAS Number | 40709-69-1 | Molecular Weight | 509.29 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20INO6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Bicuculline methiodideBicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1]. |
| Name | (-)-Bicuculline methiodide,[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinoliniumiodide |
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| Synonym | More Synonyms |
| Description | Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1]. |
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| Related Catalog | |
| In Vitro | Bicuculline methiodide (30 μM) 促进 N-甲基-d-天冬氨酸 (NMDA) 刺激，促进多巴胺神经元的爆发性放电[1]。 研究表明，反奖励中枢外侧缰核（LHb）的簇状放电是抑郁症发生的充分条件。LHb神经元常分为三类：沉默型（silent）, 强直放电型（tonic-firing），簇状放电型（burst-firing）[2]。 |
| References |
| Molecular Formula | C21H20INO6 |
|---|---|
| Molecular Weight | 509.29 |
| Exact Mass | 509.03400 |
| PSA | 63.22000 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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~99%
Bicuculline met... CAS#:40709-69-1 |
| Literature: Slavik, Jiri; Slavikova, Leonora Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 2009 - 2020 |
| Precursor 2 | |
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| DownStream 0 | |
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| bicuculine methiodide |