42061-33-6

42061-33-6 structure

Name: d [Leu4,Lys8] -VP TFA
Chemical Name: d[Leu4,Lys8]-VP
CAS Number: 42061-33-6
Molecular Formula: C₄₇H₆₇N₁₁O₁₁S₂
Molecular Weight: 1026.23000
Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
Create Date: 2017-04-24 20:32:35
Modify Date: 2024-01-05 10:13:56
D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

Name	d[Leu4,Lys8]-VP
Synonyms	MPR-TYR-PHE-LEU-ASN-CYS-PRO-LYS-GLY-NH2 3-Mercaptopropionyl-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2

Description	D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor Research Areas >> Neurological Disease
Target	vasopressin V1b receptor[1]
References	[1]. Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148(9): 4136-46. [2]. Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50(4): 835-47.

Hazard Codes	Xi