480439-73-4
480439-73-4 structure
- Name: TFB-TBOA
- Chemical Name: TFB-TBOA,(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-asparticacid
- CAS Number: 480439-73-4
- Molecular Formula: C19H17F3N2O6
- Molecular Weight: 426.34300
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel EAAT2
- Create Date: 2016-02-02 15:52:15
- Modify Date: 2024-01-04 13:42:02
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TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs[1].
| Name | TFB-TBOA,(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-asparticacid |
|---|---|
| Synonyms | tfb-tboa |
| Description | TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs[1]. |
|---|---|
| Related Catalog | |
| In Vitro | TFB-TBOA (CF3-Bza-TBOA) inhibits synaptically activated transporter currents (STCs) in astrocytes in the stratum radiatum in rat hippocampal slices in a dose-dependent manner with an IC50 of 13 nM, and reduces them to approximately 10% of the control at 100 nM[2]. TFB-TBOA inhibits the Na+i response evoked by 200 µM glutamate in a concentration-dependent manner with IC50 value of 43 nM, as measured on the amplitude of the Na+i response[1]. |
| References |
| Molecular Formula | C19H17F3N2O6 |
|---|---|
| Molecular Weight | 426.34300 |
| Exact Mass | 426.10400 |
| PSA | 138.95000 |
| LogP | 3.11270 |