Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,6-Hexanediaminium,N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2)
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: hexamethonium bromide
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Purity: 99.0%
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Contact: Anson
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55-97-0

55-97-0 structure

Name: Hexamethonium bromide
Chemical Name: hexamethonium bromide
CAS Number: 55-97-0
Molecular Formula: C₁₂H₃₀Br₂N₂
Molecular Weight: 362.188
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-06-21 15:25:25
Modify Date: 2026-07-16 10:37:30
Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3].

Name	hexamethonium bromide
Synonyms	Hexamethonium bromide,N,N,N,N',N',N'-Hexamethylhexamethylenediammoniumdibromide HEXAMETHONIUM DIBROMIDE 6-hexanediaminium,n,n,n,n’,n’,n’-hexamethyl-dibromide gangliostat Hexamethylenebis(trimethylammonium bromide) 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide (9CI) EINECS 200-249-7 Hexamethonium bromide , >= (AT) 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2) hexameton alpha,omega-bis(trimethylammonium)hexanedibromide trimethyl-[6-(trimethylazaniumyl)hexyl]azanium MFCD00011787 Methobromine hexamethylenebis(trimethyl-ammoniudibromide Hexamethonium (Bromide) esametina N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide Hexamethonium bromide,Hexane-1,6-bis(trimethylammonium bromide), N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dibromide simpatoblock N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide N,N,N,N',N',N'-HEXAMETHYLHEXAMETHYLENEDIAMMONIUM DIBROMIDE HEXAMETHONIUM BROMIDE hexamethioniumbromide vegolysen N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dibromide Hexane-1,6-bis(trimethylammonium bromide), N,N,N,Nμ,Nμ,Nμ-Hexamethylhexamethylenediammonium dibromide HEXAMETHONIUM BROMIDE HYDRATE hexoniumdibromide Hexamethonium Bromide, 10 mM in DMSO vegolysin HEXAMETHONIUM BROMIDE //BP N,N,N,N',N',N'-Hexamethyl-1,6-hexanediaminium dibromide Hexamethylenebis(trimethylammonium Bromide) Hexane-1,6-bis(trimethylammonium Bromide) HEXANE-1,6-BIS(TRIMETHYLAMMONIUM BROMIDE) HEXAMETHYLENEBIS(TRIMETHYLAMMONIUM BROMIDE) Hexamethonium bromide, nicotinic rector blocker 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide 1,6-Hexanediaminium, N,N,N,N,N,N-hexamethyl-, bromide (1:2) Hexane-1,6-bis(trimethylammonium bromide)

Description	Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Maneckjee, R. and J.D. Minna, Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ, 1994. 5(10): p. 1033-40. [2]. Sanchez-Fortun, S., F. Sanz, and M.V. Barahona, Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Arch Environ Contam Toxicol, 1996. 31(3): p. 391-8. [3]. Villablanca, A.C., Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol (1985), 1998. 84(6): p. 2089-98.

Melting Point	~285 °C (dec.)
Molecular Formula	C₁₂H₃₀Br₂N₂
Molecular Weight	362.188
Exact Mass	360.077545
Storage condition	Desiccate at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BQ8575000

CHEMICAL NAME :: Ammonium, hexamethylenebis(trimethyl-, dibromide

CAS REGISTRY NUMBER :: 55-97-0

LAST UPDATED :: 198912

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H30-N2.2Br

MOLECULAR WEIGHT :: 362.26

WISWESSER LINE NOTATION :: 1K1&1&6K1&1&1 &E 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2891 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SKNEA7 Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku, Osaka 553, Japan) No.1- 1951- Volume(issue)/page/year: 10,15,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,708,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64130 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SKNEA7 Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku, Osaka 553, Japan) No.1- 1951- Volume(issue)/page/year: 10,15,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 838 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,356,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,1307,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 91,1307,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 2,233,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SKNEA7 Shionogi Kenkyusho Nenpo. Annual Report of Shionogi Research Laboratory. (Shionogi Seiyaku K.K. Kenkyusho, 5-12-4 Sagisu, Fukushima-ku, Osaka 553, Japan) No.1- 1951- Volume(issue)/page/year: 10,15,1960 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 46 mg/kg

SEX/DURATION :: female 31-34 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year: 29,354,1954

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R22;R24/25
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	BQ8575000