57265-65-3

57265-65-3 structure

Name: Calmidazolium chloride
Chemical Name: Calmidazolium chloride,1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazoliumchloride
CAS Number: 57265-65-3
Molecular Formula: C₃₁H₂₃Cl₇N₂O
Molecular Weight: 687.698
Catalog: Signaling Pathways Neuronal Signaling CaMK
Create Date: 2016-01-31 11:47:27
Modify Date: 2024-01-14 18:58:26
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM.

Name	Calmidazolium chloride,1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazoliumchloride
Synonyms	Calmidazolium chloride COMPOUND 48/80 TRIHYDROCHLORIDE 1H-Imidazolium, 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, chloride (1:1) 1-[Bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium chloride COMPOUND 48/80 MFCD00077679 Calimidazoline CALMIDAZOLIUM

Description	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> CaMK Research Areas >> Neurological Disease
Target	Kd: 3 nM (Calmodulin)[3]
In Vitro	Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. Cell Viability Assay[2] Cell Line: Mouse F9 ECCs Concentration: 3, 5, 7, 10 μM Incubation Time: 30 minutes-24 hours Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM[2].
References	[1]. Gietzen K, et al. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J. 1983 Dec 15;216(3):611-6. [2]. Lee J, et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicol In Vitro. 2016 Sep;35:86-92. [3]. Budu A, et al. Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport