73341-72-7

73341-72-7 structure

Name: Macbecin I
Chemical Name: Macbecin I,(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
CAS Number: 73341-72-7
Molecular Formula: C₃₀H₄₂N₂O₈
Molecular Weight: 558.66300
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2016-11-06 21:30:45
Modify Date: 2024-01-15 22:56:45
Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].

Name	Macbecin I,(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
Synonyms	macbecin I

Description	Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90:2 μM (IC50) HSP90:0.24 μM (Kd)
References	[1]. Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51(9):2853-7.

WISWESSER LINE NOTATION :: T6-19- A AV DV GMV IU KU OU&TJ I1 M1 NOVZ O1 Q1 RO1 SO1 U1 VO1

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,205,1980