740980-24-9

740980-24-9 structure

Name: ACV 1
Chemical Name: acv 1
CAS Number: 740980-24-9
Molecular Formula: C₇₁H₁₀₃N₂₃O₂₅S₄
Molecular Weight: 1806.98000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2017-10-05 10:19:41
Modify Date: 2025-08-21 16:03:08
ACV1 (Vc1.1), an α-Conotoxin, is a selective α9α10 nAChR antagonist with an IC50 of 19 nM. ACV1 is ~100-fold less potent on human α9α10 vs. rat nAChRs[1].

Name	acv 1
Synonyms	gly-cys-cys-ser-asp-pro-arg-cys-asn-tyr-asp-his-pro-glu-ile-cys-nh2

Description	ACV1 (Vc1.1), an α-Conotoxin, is a selective α9α10 nAChR antagonist with an IC50 of 19 nM. ACV1 is ~100-fold less potent on human α9α10 vs. rat nAChRs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 19 nM (α9α10 nAChR), 140 nM (α6/α3β2β3), 980 nM (α6/α3β4)[1]
References	[1]. J Michael McIntosh, et al. Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochem Pharmacol. 2009 Oct 1;78(7):693-702.