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78263-90-8

78263-90-8 structure
78263-90-8 structure
  • Name: 2-Methyl-5-HT
  • Chemical Name: 2-methylserotonin
  • CAS Number: 78263-90-8
  • Molecular Formula: C11H14N2O
  • Molecular Weight: 190.24200
  • Catalog: Biochemical Amino acids and their derivatives Tryptophan derivatives
  • Create Date: 2018-03-25 08:00:00
  • Modify Date: 2024-01-04 11:07:28
  • 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].
Name 2-methylserotonin
Synonyms 2-Methyl-5-HT
Lopac-M-109
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
2-Me 5-HT
2-Methyl-5-hydroxytryptamine
Tocris-0558
Description 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].
Target

5-HT3 Receptor
In Vivo 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) significantly decreases time of immobility thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
References

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.
Density 1.242g/cm3
Boiling Point 420.9ºC at 760 mmHg
Molecular Formula C11H14N2O
Molecular Weight 190.24200
Flash Point 208.4ºC
Exact Mass 190.11100
PSA 62.04000
LogP 2.38340
Index of Refraction 1.687
WGK Germany 3
HS Code 2933990090
1292285-89-2 structure

1292285-89-2

~%

78263-90-8 structure

78263-90-8
Literature: HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian Patent: WO2011/47156 A1, 2011 ; Location in patent: Page/Page column 71 ; WO 2011/047156 A1
18658-09-8 structure

18658-09-8

~%

78263-90-8 structure

78263-90-8
Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
124224-50-6 structure

124224-50-6

~%

78263-90-8 structure

78263-90-8
Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
93654-26-3 structure

93654-26-3

~%

78263-90-8 structure

78263-90-8
Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
1076-74-0 structure

1076-74-0

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78263-90-8 structure

78263-90-8
Literature: Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J. ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
6260-86-2 structure

6260-86-2

~%

78263-90-8 structure

78263-90-8
Literature: Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J. ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
33297-04-0 structure

33297-04-0

~%

78263-90-8 structure

78263-90-8
Literature: Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J. ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
28089-03-4 structure

28089-03-4

~%

78263-90-8 structure

78263-90-8
Literature: Shaw Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320 Journal of the American Chemical Society, 1956 , vol. 78, p. 6419
23210-18-6 structure

23210-18-6

~%

78263-90-8 structure

78263-90-8
Literature: HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian Patent: WO2011/47156 A1, 2011 ; WO 2011/047156 A1
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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