2-Methyl-5-HT

Modify Date: 2025-08-23 08:42:07

2-Methyl-5-HT Structure
2-Methyl-5-HT structure
 Common Name 2-Methyl-5-HT
CAS Number 78263-90-8 Molecular Weight 190.24200
Density 1.242g/cm3 Boiling Point 420.9ºC at 760 mmHg
Molecular Formula C11H14N2O Melting Point N/A
MSDS N/A Flash Point 208.4ºC

 Use of 2-Methyl-5-HT


2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].

 Names

Name 2-methylserotonin
Synonym More Synonyms

 2-Methyl-5-HT Biological Activity

Description 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].
Target

5-HT3 Receptor

In Vivo 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) significantly decreases time of immobility thus showing anti-depressive-like effects[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3 mg/kg Administration: I.p.; 45 minutes Result: Significantly decreased time of immobility thus showing anti-depressive-like effects.
References

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

 Chemical & Physical Properties

Density 1.242g/cm3
Boiling Point 420.9ºC at 760 mmHg
Molecular Formula C11H14N2O
Molecular Weight 190.24200
Flash Point 208.4ºC
Exact Mass 190.11100
PSA 62.04000
LogP 2.38340
Index of Refraction 1.687
InChIKey WYWNEDARFVJQSG-UHFFFAOYSA-N
SMILES Cc1[nH]c2ccc(O)cc2c1CCN

 Safety Information

WGK Germany 3
HS Code 2933990090

 Synthetic Route

2-methyl-3-(2-nitroethyl)-1H-indol-5-ol structure

2-methyl-3-(2-n...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian Patent: WO2011/47156 A1, 2011 ; Location in patent: Page/Page column 71 ; WO 2011/047156 A1
3-(2-aminoethyl)-5-(benzyloxy)-2-methylindole structure

3-(2-aminoethyl...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
5-benzyloxy-2-methyl-indole structure

5-benzyloxy-2-m...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
(5-benzyloxy-2-methyl-indol-3-yl)-oxo-acetyl chloride structure

(5-benzyloxy-2-...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
5-Methoxy-2-methyl-1H-indole structure

5-Methoxy-2-met...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J. ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
5-Methoxy-2-methyl-1H-indole-3-carbaldehyde structure

5-Methoxy-2-met...

CAS#:6260-86-2

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J. ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
5-methoxy-2-methyl-3-(2-nitrovinyl)-1H-indole structure

5-methoxy-2-met...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J. ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
1H-Indole-3-ethanamine,5-methoxy-2-methyl-, hydrochloride (1:1) structure

1H-Indole-3-eth...

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2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: Shaw Journal of the American Chemical Society, 1955 , vol. 77, p. 4319,4320 Journal of the American Chemical Society, 1956 , vol. 78, p. 6419
5-methoxy-2-methyl-3-(2-nitro-ethyl)-indole structure

5-methoxy-2-met...

CAS#:23210-18-6

~%

2-Methyl-5-HT Structure

2-Methyl-5-HT

CAS#:78263-90-8

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Literature: HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian Patent: WO2011/47156 A1, 2011 ; WO 2011/047156 A1

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Methyl-5-HT
Lopac-M-109
3-(2-aminoethyl)-2-methyl-1H-indol-5-ol
2-Me 5-HT
2-Methyl-5-hydroxytryptamine
Tocris-0558
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