Name | ethyl 2-[2-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1-oxoisoquinolin-5-yl]oxypropanoate |
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Synonyms |
F1808-0160
isoquinolinone scaffold,2 |
Description | SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily[1][2]. |
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Related Catalog | |
In Vitro | SID 7969543 shows IC50s of >33,333 nM for RORα, VP-16, respectively[1]. SID 7969543 is assayed for functional activity against HEK 293T cells co-transfected with a plasmid encoding full length SF-1 and a second vector allowing expression of the luciferase gene under control of five tandem repeats of the natural SF-1 response element (SFRE). SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 values of 30 ± 15 nM[1]. |
References |
Molecular Formula | C24H24N2O7 |
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Molecular Weight | 452.45700 |
Exact Mass | 452.15800 |
PSA | 105.09000 |
LogP | 2.81480 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |
~% 868224-64-0 |
Literature: Roth, Joshua; Madoux, Franck; Hodder, Peter; Roush, William R. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 8 p. 2628 - 2632 |
Precursor 1 | |
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DownStream 0 |