DC Chemicals Limited
China
Product Name: ZM39923
Price: $98.0/10mg $268.0/50mg $468.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

273727-89-2

273727-89-2 structure

273727-89-2 structure

Name: ZM39923
Chemical Name: 2-naphtyl 2-(N-isopropyl-N-benzylamino)ethyl ketone
CAS Number: 273727-89-2
Molecular Formula: C₂₃H₂₅NO
Molecular Weight: 331.45100
Catalog: Research Areas Cancer
Create Date: 2018-10-21 08:23:07
Modify Date: 2024-01-12 05:16:44
ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

Name	2-naphtyl 2-(N-isopropyl-N-benzylamino)ethyl ketone
Synonyms	1-Propanone,3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl) 2-(N-isopropylbenzyl)aminoethyl-2-naphthylketone 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one ZM39923

Description	ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease
Target	JAK3:7.1 (pIC50) JAK1:4.4 (pIC50) EGF-R:5.6 (pIC50) Lck:5.0 (pIC50) CDK4:5.0 (pIC50) TGM2:10 nM (IC50)
In Vitro	ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3].
Cell Assay	PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum, penicillin, and streptomycin in an atmosphere of 5% CO2 and 95% air at 37°C. The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8[3].
References	[1]. Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. [2]. Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. [3]. Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197.

Molecular Formula	C₂₃H₂₅NO
Molecular Weight	331.45100
Exact Mass	331.19400
PSA	20.31000
LogP	5.32320
Storage condition	2-8℃