273727-89-2
273727-89-2 structure
- Name: ZM39923
- Chemical Name: 2-naphtyl 2-(N-isopropyl-N-benzylamino)ethyl ketone
- CAS Number: 273727-89-2
- Molecular Formula: C23H25NO
- Molecular Weight: 331.45100
- Catalog: Research Areas Cancer
- Create Date: 2018-10-21 08:23:07
- Modify Date: 2024-01-12 05:16:44
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ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
| Name | 2-naphtyl 2-(N-isopropyl-N-benzylamino)ethyl ketone |
|---|---|
| Synonyms |
1-Propanone,3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)
2-(N-isopropylbenzyl)aminoethyl-2-naphthylketone 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one ZM39923 |
| Description | ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM. |
|---|---|
| Related Catalog | |
| Target |
JAK3:7.1 (pIC50) JAK1:4.4 (pIC50) EGF-R:5.6 (pIC50) Lck:5.0 (pIC50) CDK4:5.0 (pIC50) TGM2:10 nM (IC50) |
| In Vitro | ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3]. |
| Cell Assay | PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum, penicillin, and streptomycin in an atmosphere of 5% CO2 and 95% air at 37°C. The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8[3]. |
| References |
| Molecular Formula | C23H25NO |
|---|---|
| Molecular Weight | 331.45100 |
| Exact Mass | 331.19400 |
| PSA | 20.31000 |
| LogP | 5.32320 |
| Storage condition | 2-8℃ |