Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: nonaethylene glycol
Price: ￥2528.0/1g
Purity: 94.0%
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Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: nonaethylene glycol
Price: ￥Inquiry/10kg
Purity: 95.0%
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DC Chemicals Limited
China
Product Name: Nonaethylene glycol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
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3386-18-3

3386-18-3 structure

3386-18-3 structure

Name: nonaethylene glycol
Chemical Name: nonaethylene glycol
CAS Number: 3386-18-3
Molecular Formula: C₁₈H₃₈O₁₀
Molecular Weight: 414.488
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-02-13 08:00:00
Modify Date: 2024-01-02 19:14:23
Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	nonaethylene glycol
Synonyms	polyethylene glycol 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diol EINECS 222-206-1 nonaneethylene glycol 2PE 1icj 2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Description	Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.1±0.1 g/cm3
Boiling Point	506.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₃₈O₁₀
Molecular Weight	414.488
Flash Point	260.0±28.7 °C
Exact Mass	414.246490
PSA	114.30000
LogP	-4.02
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.464

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5400000

CHEMICAL NAME :: Nonaethylene glycol

CAS REGISTRY NUMBER :: 3386-18-3

BEILSTEIN REFERENCE NO. :: 1804294

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H38-O10

MOLECULAR WEIGHT :: 414.56

WISWESSER LINE NOTATION :: Q2/O2/ 8Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

RTECS	RA5400000
HS Code	2909499000

Precursor 8
105891-55-2 246832-16-6 112-27-6 669556-53-0
55489-58-2 2615-15-8 84131-04-4 42607-87-4
DownStream 1
103304-45-6

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%