nonaethylene glycol

Modify Date: 2024-01-02 19:14:23

nonaethylene glycol Structure
nonaethylene glycol structure
Common Name nonaethylene glycol
CAS Number 3386-18-3 Molecular Weight 414.488
Density 1.1±0.1 g/cm3 Boiling Point 506.2±45.0 °C at 760 mmHg
Molecular Formula C18H38O10 Melting Point N/A
MSDS N/A Flash Point 260.0±28.7 °C

 Use of nonaethylene glycol


Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name nonaethylene glycol
Synonym More Synonyms

 nonaethylene glycol Biological Activity

Description Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 506.2±45.0 °C at 760 mmHg
Molecular Formula C18H38O10
Molecular Weight 414.488
Flash Point 260.0±28.7 °C
Exact Mass 414.246490
PSA 114.30000
LogP -4.02
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.464

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RA5400000
CHEMICAL NAME :
Nonaethylene glycol
CAS REGISTRY NUMBER :
3386-18-3
BEILSTEIN REFERENCE NO. :
1804294
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H38-O10
MOLECULAR WEIGHT :
414.56
WISWESSER LINE NOTATION :
Q2/O2/ 8Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

 Safety Information

RTECS RA5400000
HS Code 2909499000

 Synthetic Route

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

polyethylene glycol
3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diol
EINECS 222-206-1
nonaneethylene glycol
2PE
1icj
2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
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