- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Ara-G
- Price: Check
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Ara-G
- Price: ￥5656.0/10g ￥3766.0/5g ￥746.0/250mg ￥1876.0/1g
- Purity: 95.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Ara-G
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Ara-G
- Price: $300.0/100mg $600.0/250mg $1200.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 6H-Purin-6-one,2-amino-9-b-D-arabinofuranosyl-1,9-dihydro-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
38819-10-2
38819-10-2 structure
- Name: Ara-G
- Chemical Name: 9-β-D-arabinofuranosylguanine
- CAS Number: 38819-10-2
- Molecular Formula: C10H13N5O5
- Molecular Weight: 283.241
- Catalog: Biochemical Carbohydrate Monosaccharide
- Create Date: 2018-03-22 08:00:00
- Modify Date: 2025-08-25 13:10:15
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9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2].
| Name | 9-β-D-arabinofuranosylguanine |
|---|---|
| Synonyms |
9-beta-D-arabinofuranosylguanine
2-Amino-9-(β-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one Arabinosylguanine Ara-G 9-arabinofuranosylguanine 9-b-D-Arabinofuranosylguanine 6H-Purin-6-one, 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro- ARABINOFURANOSYL-GUANINE 9-β-D-Arabinofuranosylguanine Hydrate 9-Arabinoguanine GUANINE-9-ARABINOSIDE |
| Description | 9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Km: 8.0 μM (dGK)[2] |
| In Vitro | 9-β-D-Arabinofuranosylguanine 通过其 5 ' -三磷酸腺苷 Ara-GTP 在细胞内的积累引起细胞毒性，Ara-GTP 抑制 DNA 聚合酶和核糖核苷酸还原酶，并入 DNA，终止 DNA 链伸长，导致细胞死亡[1][2]。 9-β-D-Arabinofuranosylguanine 对培养的 T 淋巴母细胞具有选择性毒性，因为相对于 B- 和无淋巴母细胞，它们能够积累更高水平的细胞毒性代谢物 Ara-GTP[1]。 9-β-D-Arabinofuranosylguanine (0-1000 μM; 72 h) 具有细胞毒性，对 MOLT-4、MOLT-4/Ara-G500 和 MOLT-4/Ara-G900 的 IC50 分别为 4.2、452 和 777 μM[2]。 Cell Viability Assay[2] Cell Line: MOLT-4 and Ara-G-resistant sublines: MOLT-4/Ara-G500 and MOLT-4/Ara-G900 Concentration: 0-1000 μM Incubation Time: 72 h Result: Showed cytotoxicity with IC50s of 4.2, 452 and 777 μM against MOLT-4, MOLT-4/Ara-G500 and MOLT-4/Ara-G900 cells, respectively. |
| References |
| Density | 2.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 775.9ºC at 760 mmHg |
| Melting Point | 225°C(lit.) |
| Molecular Formula | C10H13N5O5 |
| Molecular Weight | 283.241 |
| Flash Point | 423.1ºC |
| Exact Mass | 283.091675 |
| PSA | 159.51000 |
| LogP | -1.72 |
| Index of Refraction | 1.955 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: >10mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
|
| Hazard Codes | Xn |
|---|---|
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26 |
| RTECS | MF8301000 |
| HS Code | 2934999090 |
| Precursor 0 | |
|---|---|
| DownStream 3 | |
![2-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione structure](https://image.chemsrc.com/caspic/203/32976-84-4.png)
![[3,4-diacetyloxy-5-(2-amino-6-sulfanylidene-3H-purin-9-yl)oxolan-2-yl]methyl acetate structure](https://image.chemsrc.com/caspic/272/34793-14-1.png)
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |