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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: 6H-Purin-6-one,2-amino-9-b-D-arabinofuranosyl-1,9-dihydro-
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38819-10-2

38819-10-2 structure

Name: Ara-G
Chemical Name: 9-β-D-arabinofuranosylguanine
CAS Number: 38819-10-2
Molecular Formula: C₁₀H₁₃N₅O₅
Molecular Weight: 283.241
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-03-22 08:00:00
Modify Date: 2024-01-02 19:00:53
9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2].

Name	9-β-D-arabinofuranosylguanine
Synonyms	9-beta-D-arabinofuranosylguanine 2-Amino-9-(β-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one Arabinosylguanine Ara-G 9-arabinofuranosylguanine 9-b-D-Arabinofuranosylguanine 6H-Purin-6-one, 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro- ARABINOFURANOSYL-GUANINE 9-β-D-Arabinofuranosylguanine Hydrate 9-Arabinoguanine GUANINE-9-ARABINOSIDE

Description	9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Km: 8.0 μM (dGK)[2]
In Vitro	9-β-D-Arabinofuranosylguanine 通过其 5 ' -三磷酸腺苷 Ara-GTP 在细胞内的积累引起细胞毒性，Ara-GTP 抑制 DNA 聚合酶和核糖核苷酸还原酶，并入 DNA，终止 DNA 链伸长，导致细胞死亡[1][2]。 9-β-D-Arabinofuranosylguanine 对培养的 T 淋巴母细胞具有选择性毒性，因为相对于 B- 和无淋巴母细胞，它们能够积累更高水平的细胞毒性代谢物 Ara-GTP[1]。 9-β-D-Arabinofuranosylguanine (0-1000 μM; 72 h) 具有细胞毒性，对 MOLT-4、MOLT-4/Ara-G500 和 MOLT-4/Ara-G900 的 IC50 分别为 4.2、452 和 777 μM[2]。 Cell Viability Assay[2] Cell Line: MOLT-4 and Ara-G-resistant sublines: MOLT-4/Ara-G500 and MOLT-4/Ara-G900 Concentration: 0-1000 μM Incubation Time: 72 h Result: Showed cytotoxicity with IC50s of 4.2, 452 and 777 μM against MOLT-4, MOLT-4/Ara-G500 and MOLT-4/Ara-G900 cells, respectively.
References	[1]. Shewach DS, et al. Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells. Cancer Res. 1989 Dec 1;49(23):6498-502. [2]. Lotfi K, et al. Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. Biochem Biophys Res Commun. 2002 May 24;293(5):1489-96.

Density	2.3±0.1 g/cm3
Boiling Point	775.9ºC at 760 mmHg
Melting Point	225°C(lit.)
Molecular Formula	C₁₀H₁₃N₅O₅
Molecular Weight	283.241
Flash Point	423.1ºC
Exact Mass	283.091675
PSA	159.51000
LogP	-1.72
Index of Refraction	1.955
Storage condition	2-8°C
Water Solubility	DMSO: >10mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8301000

CHEMICAL NAME :: Guanine, 9-(beta-D-arabinofuranosyl)-

CAS REGISTRY NUMBER :: 38819-10-2

LAST UPDATED :: 198806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FVM INJ HZ B1- BT5OTJ CQ DQ EQ -D, BETA, ARAB

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,1008,1985

Hazard Codes	Xn
Risk Phrases	R22;R36/37/38
Safety Phrases	S26
RTECS	MF8301000
HS Code	2934999090

Precursor 0
DownStream 3
78842-13-4 32976-84-4 34793-14-1

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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