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518-11-6

518-11-6 structure
518-11-6 structure
  • Name: COLCHICEINE, N-DEACETYL-N-METHYL-
  • Chemical Name: (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
  • CAS Number: 518-11-6
  • Molecular Formula: C20H23NO5
  • Molecular Weight: 357.40000
  • Create Date: 2017-12-15 16:29:49
  • Modify Date: 2024-01-05 12:38:18
Name (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Synonyms Demecolcein
(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one
demecolceine
(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one
(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on
N-Desacetyl-N-methylcolchiceine
Density 1.27g/cm3
Boiling Point 626.4ºC at 760 mmHg
Molecular Formula C20H23NO5
Molecular Weight 357.40000
Flash Point 332.6ºC
Exact Mass 357.15800
PSA 77.02000
LogP 3.04280
Index of Refraction 1.608

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0600000
CHEMICAL NAME :
Colchiceine, N-deacetyl-N-methyl-
CAS REGISTRY NUMBER :
518-11-6
LAST UPDATED :
198712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H23-N-O5
MOLECULAR WEIGHT :
357.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

Chemsrc provides CAS#:518-11-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 518-11-6 | Chemsrc address: https://m.chemsrc.com/en/baike/757650.html

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