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3482-37-9

3482-37-9 structure
3482-37-9 structure
  • Name: Trimethylcolchicinic acid
  • Chemical Name: N-Deacetyl Colchiceine
  • CAS Number: 3482-37-9
  • Molecular Formula: C19H21NO5
  • Molecular Weight: 343.37400
  • Catalog: analytical chemistry Standard Forensic and veterinary standards
  • Create Date: 2018-05-15 08:00:00
  • Modify Date: 2025-08-25 18:17:39
  • Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.
Name N-Deacetyl Colchiceine
Synonyms trimethylcolchicinic acid
Density 1.32g/cm3
Boiling Point 629ºC at 760mmHg
Melting Point >230ºC (dec.)
Molecular Formula C19H21NO5
Molecular Weight 343.37400
Flash Point 334.2ºC
Exact Mass 343.14200
PSA 91.01000
LogP 3.09150
Index of Refraction 1.628
Storage condition −20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0960000
CHEMICAL NAME :
Colchicinic acid, trimethyl-
CAS REGISTRY NUMBER :
3482-37-9
BEILSTEIN REFERENCE NO. :
3008992
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C19-H21-N-O5
MOLECULAR WEIGHT :
343.41
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JZ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Hazard Codes Xn: Harmful;
Risk Phrases 20/21/22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GH0960000
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