DC Chemicals Limited
China
Product Name: Trimethylcolchicinic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (7S)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

3482-37-9

3482-37-9 structure

Name: Trimethylcolchicinic acid
Chemical Name: N-Deacetyl Colchiceine
CAS Number: 3482-37-9
Molecular Formula: C₁₉H₂₁NO₅
Molecular Weight: 343.37400
Catalog: analytical chemistry Standard Forensic and veterinary standards
Create Date: 2018-05-15 08:00:00
Modify Date: 2024-01-19 06:12:20
Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.

Name	N-Deacetyl Colchiceine
Synonyms	trimethylcolchicinic acid

Density	1.32g/cm3
Boiling Point	629ºC at 760mmHg
Melting Point	>230ºC (dec.)
Molecular Formula	C₁₉H₂₁NO₅
Molecular Weight	343.37400
Flash Point	334.2ºC
Exact Mass	343.14200
PSA	91.01000
LogP	3.09150
Index of Refraction	1.628
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0960000

CHEMICAL NAME :: Colchicinic acid, trimethyl-

CAS REGISTRY NUMBER :: 3482-37-9

BEILSTEIN REFERENCE NO. :: 3008992

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H21-N-O5

MOLECULAR WEIGHT :: 343.41

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JZ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GH0960000

Precursor 7
64-86-8 477-27-0 73307-44-5 7469-68-3
7664-93-9 7647-01-0 67-56-1
DownStream 7
3476-50-4 47477-04-3 477-27-0 477-30-5
1850-57-3 518-11-6 75520-89-7

3482-37-9	73307-44-5
3476-50-4	49720-72-1
2432-85-1	2432-81-7
2432-46-4	11043-91-7
243869-48-9	105603-54-1
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
1251578-98-9	6906-52-1
930439-75-1	1218726-78-3
1214641-27-6	1021077-03-1