Name | 5.α.-Eupha-8,24-dien-3.β.-ol |
---|---|
Synonyms |
13α,14β,17βH-Lanosta-8,24-dien-3β-ol (8CI)
Euphadienol (3β,13α,14β,17α)-Lanosta-8,24-dien-3-ol 5α-Eupha-8,24-dien-3β-ol Euphol, Euphadienol euphol Lanosta-8,24-dien-3-ol, (3β,13α,14β,17α)- |
Description | Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1]. |
---|---|
Related Catalog | |
Target |
IC50: 315 nM (monoacylglycerol lipase activity)[1] |
In Vitro | Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively[2]. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins[2]. Cell Proliferation Assay[2] Cell Line: T47D cells Concentration: 0.01, 0.03, 0.1 and 0.3 mM Incubation Time: 24, 48 and 72 hours Result: Decreased the percentage of viable cells. Western Blot Analysis[2] Cell Line: T47D cells Concentration: 0.03 mM Incubation Time: 48 and 72 hours Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D. |
References |
Density | 1.0±0.1 g/cm3 |
---|---|
Boiling Point | 498.9±44.0 °C at 760 mmHg |
Melting Point | 116-117ºC |
Molecular Formula | C30H50O |
Molecular Weight | 426.717 |
Flash Point | 221.1±20.7 °C |
Exact Mass | 426.386169 |
PSA | 20.23000 |
LogP | 11.00 |
Vapour Pressure | 0.0±2.9 mmHg at 25°C |
Index of Refraction | 1.530 |
Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|