110953-39-4

110953-39-4 structure

Name: 3-Methyladenine-d3
Chemical Name: 3-(trideuteriomethyl)purin-6-amine
CAS Number: 110953-39-4
Molecular Formula: C₆H₄D₃N₅
Molecular Weight: 152.17200
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2017-04-26 03:42:59
Modify Date: 2026-07-01 16:23:47
3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

Name	3-(trideuteriomethyl)purin-6-amine
Synonyms	3-(Methyl-d3)-3H-purin-6-aMine N3-(Methyl-d3)adenine 3-(Methyl-d3)-3H-purin-6-amine 3-Methyl-d3-adenine 3-(Methyl-d3)-6-aMinopurine 6-Amino-3-(Methyl-d3)purine 3-(Methyl-d3)-6-aminopurine NSC 66389-d3 3-Methyl Adenine-d3 6-Amino-3-(methyl-d3)purine 3-Methyladenine (methyl-D, ) [2H3]-3-Methyl Adenine

Description	3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7. [3]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 20127(4):e35665. [4]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 20162016:8369704.