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  • DC Chemicals Limited
  • China
  • Product Name: ESI-05
  • Price: $250.0/100mg $450.0/250mg $900.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

5184-64-5

5184-64-5 structure
5184-64-5 structure
  • Name: ESI 05
  • Chemical Name: 1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene
  • CAS Number: 5184-64-5
  • Molecular Formula: C16H18O2S
  • Molecular Weight: 274.37800
  • Catalog: Research Areas Others
  • Create Date: 2016-12-18 06:41:12
  • Modify Date: 2024-01-11 20:18:50
  • ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].

Name 1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene
Synonyms mesityl(4-methylphenyl) sulfone
Description ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].
Related Catalog
Target

IC50: 0.4 µM (EPAC2)[1]

References

[1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.

Density 1.129g/cm3
Boiling Point 426.7ºC at 760mmHg
Molecular Formula C16H18O2S
Molecular Weight 274.37800
Flash Point 250ºC
Exact Mass 274.10300
PSA 42.52000
LogP 4.83380
Index of Refraction 1.562