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67287-39-2

67287-39-2 structure
67287-39-2 structure
  • Name: SKF 81297 hydrobromide
  • Chemical Name: (R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
  • CAS Number: 67287-39-2
  • Molecular Formula: C16H17BrClNO2
  • Molecular Weight: 370.669
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2018-12-28 13:18:29
  • Modify Date: 2024-01-04 13:35:08
  • SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].

Name (R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
Synonyms R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, (1R)-, hydrobromide (1:1)
R-(+)-SKF-81297 hydrobromide
(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1)
6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
(1R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1)
Metastin (human)
(R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, hydrobromide (1:1)
(+/-)-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrobromide
Description SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].
Related Catalog
Target

D1 Receptor

In Vivo SKF 81297 hydrobromide (0.05-0.3 mg/kg,肌注,一次) 刺激 MPTP 损伤猴子的运动行为[1]。 Animal Model: Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] Dosage: 0.05-0.3 mg/kg Administration: Injected intramuscularly (i.m.), once Result: Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.
References

[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7.  

[2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.  

Molecular Formula C16H17BrClNO2
Molecular Weight 370.669
Exact Mass 369.013123
PSA 52.49000
LogP 4.31570
WGK Germany 3
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%