SKF 81297 hydrobromide

Modify Date: 2025-08-25 13:40:20

SKF 81297 hydrobromide structure	Common Name	SKF 81297 hydrobromide
	CAS Number	67287-39-2	Molecular Weight	370.669
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₇BrClNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SKF 81297 hydrobromide

SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].

Name	(R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
Synonym	More Synonyms

Description	SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor
In Vivo	SKF 81297 hydrobromide (0.05-0.3 mg/kg，肌注，一次) 刺激 MPTP 损伤猴子的运动行为[1]。 Animal Model: Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] Dosage: 0.05-0.3 mg/kg Administration: Injected intramuscularly (i.m.), once Result: Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.
References	[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.

Molecular Formula	C₁₆H₁₇BrClNO₂
Molecular Weight	370.669
Exact Mass	369.013123
PSA	52.49000
LogP	4.31570
InChIKey	RMIJGBMRNYUZRG-UHFFFAOYSA-N
SMILES	Br.Oc1cc2c(c(Cl)c1O)CCNCC2c1ccccc1

WGK Germany	3
HS Code	2933990090

Precursor 9
CAS#:67287-38-1 6-chloro-7,8-di... CAS#:621-59-0 Isovanillin CAS#:67287-37-0 N-(2-Hydroxy-2-... CAS#:93983-14-3 2-chloro-1-(chl...
CAS#:5417-17-4 2-Chloro-3,4-di... CAS#:37687-57-3 2-Chloro-3-hydr... CAS#:67287-36-9 2-(2-Chloro-3,4... CAS#:7537-07-7 (2-chloro-3,4-d...
CAS#:93983-13-2 (2-Chloro-3,4-d...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS

Name: qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali...
Source: NCGC
External Id: adst_MBL_Abs_LOPAC_o1

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Renal vasodilator activity was determined in anesthetized dogs
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL664304

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Central dopaminergic activity for minimum concentration which produced 500 rotations(...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL794227

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE

1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, (1R)-, hydrobromide (1:1)

R-(+)-SKF-81297 hydrobromide

(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1)

6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

(1R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide (1:1)

Metastin (human)

(R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide

1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-, hydrobromide (1:1)

(+/-)-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrobromide

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SKF 81297 hydrobromide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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SKF 81297 hydrobromide

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