153504-81-5
153504-81-5 structure
- Name: Licostinel
- Chemical Name: 6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione
- CAS Number: 153504-81-5
- Molecular Formula: C8H3Cl2N3O4
- Molecular Weight: 276.03
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-04-15 08:00:00
- Modify Date: 2025-08-25 23:40:51
-
Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3].
| Name | 6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione |
|---|---|
| Synonyms |
6,7-Dichloro-5-nitro-2,3-quinoxalinedione
Licostinel 5-Nitro-6,7-dichloro-2,3-quinoxalinedione 2,3-Quinoxalinedione,6,7-dichloro-1,4-dihydro-5-nitro 5-nitro-6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione ACEA-1021 6,7-dichloro-1,4-dihydro-8-nitro-2,3-quinoxalinedione 1,4-dihydro-6,7-dichloro-5-nitroquinoxalin-2,3-dione 6,7-Dichloro-1,4-dihydro-5-nitro-2,3-quinoxalinedione |
| Description | Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
59 nM (glycine receptor)[1] |
| References |
| Density | 1.757g/cm3 |
|---|---|
| Molecular Formula | C8H3Cl2N3O4 |
| Molecular Weight | 276.03 |
| Exact Mass | 274.95000 |
| PSA | 111.54000 |
| LogP | 1.95460 |
| Index of Refraction | 1.647 |
|
~93%
153504-81-5 |
| Literature: Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379 |
|
~88%
153504-81-5 |
| Literature: Kher, Sunil M.; Cai, Sui Xiong; Weber, Eckard; Keana, John F. W. Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5838 - 5842 |
|
~%
153504-81-5 |
| Literature: Kher, Sunil M.; Cai, Sui Xiong; Weber, Eckard; Keana, John F. W. Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5838 - 5842 |
|
~%
153504-81-5 |
| Literature: Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379 |
|
~%
153504-81-5 |
| Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353 |
|
~%
153504-81-5 |
| Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353 |
|
~%
153504-81-5 |
| Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353 |
| Precursor 7 | |
|---|---|
| DownStream 1 | |
