Licostinel

Modify Date: 2025-08-25 23:40:51

Licostinel structure	Common Name	Licostinel
	CAS Number	153504-81-5	Molecular Weight	276.03
	Density	1.757g/cm3	Boiling Point	N/A
	Molecular Formula	C₈H₃Cl₂N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Licostinel

Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3].

Name	6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione
Synonym	More Synonyms

Description	Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	59 nM (glycine receptor)[1]
References	[1]. Zhou ZL, et al. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorg Med Chem. 2003 Apr 17;11(8):1769-80. [2]. Albers GW, et al. Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke. 1999 Mar;30(3):508-13. [3]. Martin H, et al. Effects of glycine receptor antagonism on spreading depression in the rat. Neurosci Lett. 1994 Oct 24;180(2):285-9.

Density	1.757g/cm3
Molecular Formula	C₈H₃Cl₂N₃O₄
Molecular Weight	276.03
Exact Mass	274.95000
PSA	111.54000
LogP	1.95460
Index of Refraction	1.647

6,7-Dichloro-1,...

CAS#:25983-13-5

~93%

Licostinel

CAS#:153504-81-5

Literature: Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379

6,7-Dichloro-3,...

CAS#:153505-40-9

~88%

Licostinel

CAS#:153504-81-5

Literature: Kher, Sunil M.; Cai, Sui Xiong; Weber, Eckard; Keana, John F. W. Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5838 - 5842

6,7-Dichloroqui...

CAS#:78470-95-8

Licostinel

CAS#:153504-81-5

Literature: Kher, Sunil M.; Cai, Sui Xiong; Weber, Eckard; Keana, John F. W. Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5838 - 5842

4,5-dichlorbenz...

CAS#:5348-42-5

Licostinel

CAS#:153504-81-5

Literature: Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379

5,6-dichloro-2,...

CAS#:21641-42-9

Licostinel

CAS#:153504-81-5

Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353

Diethyloxalate

CAS#:95-92-1

4,5-Dichloro-3-...

CAS#:276238-86-9

Licostinel

CAS#:153504-81-5

4,5-dichlorbenz...

CAS#:5348-42-5

Diethyloxalate

CAS#:95-92-1

Licostinel

CAS#:153504-81-5

Precursor 7
CAS#:25983-13-5 6,7-Dichloro-1,... CAS#:153505-40-9 6,7-Dichloro-3,... CAS#:78470-95-8 6,7-Dichloroqui... CAS#:5348-42-5 4,5-dichlorbenz...
CAS#:21641-42-9 5,6-dichloro-2,... CAS#:95-92-1 Diethyloxalate CAS#:276238-86-9 4,5-Dichloro-3-...
DownStream 1
CAS#:178619-89-1 6,7-DICHLOOR-2,...

6,7-Dichloro-5-nitro-2,3-quinoxalinedione

Licostinel

5-Nitro-6,7-dichloro-2,3-quinoxalinedione

2,3-Quinoxalinedione,6,7-dichloro-1,4-dihydro-5-nitro

5-nitro-6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione

ACEA-1021

6,7-dichloro-1,4-dihydro-8-nitro-2,3-quinoxalinedione

1,4-dihydro-6,7-dichloro-5-nitroquinoxalin-2,3-dione

6,7-Dichloro-1,4-dihydro-5-nitro-2,3-quinoxalinedione

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Licostinel
Price: Check
Purity: 98.02%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Licostinel
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥700/5 mg

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Licostinel

Use of Licostinel

Names

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Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.