11041-94-4

11041-94-4 structure

Name: Higenamine HCl
Chemical Name: 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
CAS Number: 11041-94-4
Molecular Formula: C₁₆H₁₈ClNO₃
Molecular Weight: 307.772
Catalog: Biochemical Plant extracts
Create Date: 2018-02-22 08:00:00
Modify Date: 2026-07-02 18:36:01
Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].

Name	1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
Synonyms	(±)-Higenamine (hydrochloride) 6,7-DIHYDROXY-1-(4-HYDROXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHL (+/-)-Higenamine HCl - natural 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1) 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride AI3-01335 AI3 Higenamine hydrochloride-RM 1,2,3,4-Tetrahydro-1-[(4-hydroxy-phenyl)methyl]-6,7-isoquinolinediol HCl (+/-)-Higenamine HCl Higenamine HCl\|\|\|Demethylcoclaurine hydrochloride\|\|\|norcoclaurine HCl\|\|\|(+-)-Demethylcoclaurine hydrochloride\|\|\|Higenamineu00A0Hydrochloride (+/-)-Higenamine HCl - synthetic Higenamine hydrochloride, 10 mM in DMSO AI301335 Higenamine hydrochloride norcoclaurine hcl Demethyl Trelagllptin Dacacine base acid and alkali salt 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1) D4-Higenamine hydrochloride Demethyl Norcoclaurine hydrochloride 1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol hydrochloride 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one _x000D_6，7-Dihydroxy-1-(4-Hydroxybenzyl)-1，2，3，4-tetrahydroisoquinoline Hydrochloride 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline (+/-)-Higenamine HCl - synthetic - Bio-X UNII:PQ432PID6E 6,7-Dihydroxy-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-Isoquinolinediol hydrochloride (1:1) 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)

Description	Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Endocrinology
Target	β2-AR[1]
References	[1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23. [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

Boiling Point	522.4ºC at 760 mmHg
Molecular Formula	C₁₆H₁₈ClNO₃
Molecular Weight	307.772
Flash Point	209.6ºC
Exact Mass	307.097534
PSA	72.72000
LogP	3.36370
Vapour Pressure	1.56E-11mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX0484380

CHEMICAL NAME :: 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 11041-94-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H17-N-O3.Cl-H

MOLECULAR WEIGHT :: 307.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

HS Code	2933499090