86770-68-5

86770-68-5 structure

Name: Azido-PEG5-alcohol
Chemical Name: 14-Azido-3,6,9,12-tetraoxatetradecanol
CAS Number: 86770-68-5
Molecular Formula: C₁₀H₂₁N₃O₅
Molecular Weight: 263.291
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2019-01-10 15:28:32
Modify Date: 2024-01-02 22:26:38
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	14-Azido-3,6,9,12-tetraoxatetradecanol
Synonyms	3,6,9,12-Tetraoxatetradecan-1-ol, 14-azido- 14-Azido-3,6,9,12-tetraoxatetradecan-1-ol 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol

Description	Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20. [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.