Azido-PEG5-alcohol

Modify Date: 2024-01-02 22:26:38

Azido-PEG5-alcohol Structure
Azido-PEG5-alcohol structure
Common Name Azido-PEG5-alcohol
CAS Number 86770-68-5 Molecular Weight 263.291
Density N/A Boiling Point N/A
Molecular Formula C10H21N3O5 Melting Point N/A
MSDS N/A Flash Point 100 °C

 Use of Azido-PEG5-alcohol


Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

 Names

Name 14-Azido-3,6,9,12-tetraoxatetradecanol
Synonym More Synonyms

 Azido-PEG5-alcohol Biological Activity

Description Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog
Target

PEGs

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20.

[2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.

 Chemical & Physical Properties

Molecular Formula C10H21N3O5
Molecular Weight 263.291
Flash Point 100 °C
Exact Mass 263.148132
PSA 106.90000
LogP -1.59
Index of Refraction 1.47

 Synonyms

3,6,9,12-Tetraoxatetradecan-1-ol, 14-azido-
14-Azido-3,6,9,12-tetraoxatetradecan-1-ol
2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol
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