Azido-PEG5-alcohol structure
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Common Name | Azido-PEG5-alcohol | ||
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CAS Number | 86770-68-5 | Molecular Weight | 263.291 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H21N3O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 100 °C |
Use of Azido-PEG5-alcoholAzido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
Name | 14-Azido-3,6,9,12-tetraoxatetradecanol |
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Synonym | More Synonyms |
Description | Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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Related Catalog | |
Target |
PEGs Non-cleavable |
In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
References |
[2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1. |
Molecular Formula | C10H21N3O5 |
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Molecular Weight | 263.291 |
Flash Point | 100 °C |
Exact Mass | 263.148132 |
PSA | 106.90000 |
LogP | -1.59 |
Index of Refraction | 1.47 |
3,6,9,12-Tetraoxatetradecan-1-ol, 14-azido- |
14-Azido-3,6,9,12-tetraoxatetradecan-1-ol |
2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol |