82-88-2

82-88-2 structure

Name: phenindamine
Chemical Name: 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
CAS Number: 82-88-2
Molecular Formula: C₁₉H₁₉N
Molecular Weight: 261.36100
Catalog: Organic raw materials Organic fluorine compound Fluorobenzonitrile series
Create Date: 2018-04-26 08:00:00
Modify Date: 2024-01-10 12:24:01
Phenindamine (Nu 1504) is an antihistamine[1].

Name	2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
Synonyms	Fenindamina Phenindamine (INN) Phenindamine [INN:BAN] Phenindaminum 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine Nolahist 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridin Phenindiamine Phenindamin Phenindaminum [INN-Latin] Fenindamina [INN-Spanish] Thephorin Phenindamine

Description	Phenindamine (Nu 1504) is an antihistamine[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vivo	Phenindamine (2-10 mg/kg; i.p.; once) shows performance enhancement effect in rats[1]. Animal Model: Adult male Long-Evans strain rats[1] Dosage: 2, 5 and 10 mg/kg Administration: Intraperitoneal injection, once Result: Decreased attention index (AI) and increase the AI variance. Produced a dose-related increase in the performance index (PI).

Density	1.15g/cm3
Boiling Point	416.5ºC at 760 mmHg
Melting Point	90-91°
Molecular Formula	C₁₉H₁₉N
Molecular Weight	261.36100
Flash Point	183ºC
Exact Mass	261.15200
PSA	3.24000
LogP	3.85910
Index of Refraction	1.652

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK9460500

CHEMICAL NAME :: 1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-

CAS REGISTRY NUMBER :: 82-88-2

BEILSTEIN REFERENCE NO. :: 0221083

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H19-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,350,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,271,1970

71839-14-0

82-88-2

Literature: Hoffmann-La Roche Patent: DE820141 , 1951 ; Full Text Show Details Hoffmann-La Roche Patent: US2470108 , 1947 ; DRP/DRBP Org.Chem. Full Text Show Details Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

60295-97-8

82-88-2

Literature: Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

64-17-5

71839-14-0

82-88-2

Literature: Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

Precursor 3
71839-14-0 60295-97-8 64-17-5
DownStream 0

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