phenindamine

Modify Date: 2025-08-25 14:35:46

phenindamine structure	Common Name	phenindamine
	CAS Number	82-88-2	Molecular Weight	261.36100
	Density	1.15g/cm3	Boiling Point	416.5ºC at 760 mmHg
	Molecular Formula	C₁₉H₁₉N	Melting Point	90-91°
	MSDS	N/A	Flash Point	183ºC

Use of phenindamine

Phenindamine (Nu 1504) is an antihistamine[1].

Name	2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
Synonym	More Synonyms

Description	Phenindamine (Nu 1504) is an antihistamine[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vivo	Phenindamine (2-10 mg/kg; i.p.; once) shows performance enhancement effect in rats[1]. Animal Model: Adult male Long-Evans strain rats[1] Dosage: 2, 5 and 10 mg/kg Administration: Intraperitoneal injection, once Result: Decreased attention index (AI) and increase the AI variance. Produced a dose-related increase in the performance index (PI).

Density	1.15g/cm3
Boiling Point	416.5ºC at 760 mmHg
Melting Point	90-91°
Molecular Formula	C₁₉H₁₉N
Molecular Weight	261.36100
Flash Point	183ºC
Exact Mass	261.15200
PSA	3.24000
LogP	3.85910
Index of Refraction	1.652

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK9460500

CHEMICAL NAME :: 1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-

CAS REGISTRY NUMBER :: 82-88-2

BEILSTEIN REFERENCE NO. :: 0221083

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H19-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,350,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,271,1970

2,3-dihydro-2-m...

CAS#:71839-14-0

phenindamine

CAS#:82-88-2

Literature: Hoffmann-La Roche Patent: DE820141 , 1951 ; Full Text Show Details Hoffmann-La Roche Patent: US2470108 , 1947 ; DRP/DRBP Org.Chem. Full Text Show Details Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

2-methyl-9-phen...

CAS#:60295-97-8

phenindamine

CAS#:82-88-2

Literature: Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

Ethanol

CAS#:64-17-5

2,3-dihydro-2-m...

CAS#:71839-14-0

phenindamine

CAS#:82-88-2

Literature: Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

Precursor 3
CAS#:71839-14-0 2,3-dihydro-2-m... CAS#:60295-97-8 2-methyl-9-phen... CAS#:64-17-5 Ethanol
DownStream 0

Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801

Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791

Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr

Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP

Name: Binding affinity towards human DRD2 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL5291781

Name: Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol...
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL5291777

Name: Binding affinity towards human DRD3 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(3) dopamine receptor
External Id: CHEMBL5291899

Name: Binding affinity towards human CNR1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Cannabinoid receptor 1
External Id: CHEMBL5291773

Name: Binding affinity towards human MC4R in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Melanocortin receptor 4
External Id: CHEMBL5291832

Total 78, Current Page 1 of 8

Fenindamina

Phenindamine (INN)

Phenindamine [INN:BAN]

Phenindaminum

2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine

Nolahist

2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridin

Phenindiamine

Phenindamin

Phenindaminum [INN-Latin]

Fenindamina [INN-Spanish]

Thephorin

Phenindamine

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HEALTH HAZARD DATA

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Precursor & DownStream

phenindamineBioassay

Synonyms

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