phenindamine

Modify Date: 2026-07-01 14:04:45

phenindamine Structure
phenindamine structure
Common Name phenindamine
CAS Number 82-88-2 Molecular Weight 261.36100
Density 1.15g/cm3 Boiling Point 416.5ºC at 760 mmHg
Molecular Formula C19H19N Melting Point 90-91°
MSDS N/A Flash Point 183ºC

 Use of phenindamine


Phenindamine (Nu 1504) is an antihistamine[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
Synonym More Synonyms

 phenindamine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Phenindamine (Nu 1504) is an antihistamine[1].
Related Catalog
In Vivo Phenindamine (2-10 mg/kg; i.p.; once) shows performance enhancement effect in rats[1]. Animal Model: Adult male Long-Evans strain rats[1] Dosage: 2, 5 and 10 mg/kg Administration: Intraperitoneal injection, once Result: Decreased attention index (AI) and increase the AI variance. Produced a dose-related increase in the performance index (PI).

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.15g/cm3
Boiling Point 416.5ºC at 760 mmHg
Melting Point 90-91°
Molecular Formula C19H19N
Molecular Weight 261.36100
Flash Point 183ºC
Exact Mass 261.15200
PSA 3.24000
LogP 3.85910
Index of Refraction 1.652

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK9460500
CHEMICAL NAME :
1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl-
CAS REGISTRY NUMBER :
82-88-2
BEILSTEIN REFERENCE NO. :
0221083
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H19-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
129 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,350,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
265 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 188,271,1970

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~%

phenindamine Structure

phenindamine

CAS#:82-88-2

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Literature: Hoffmann-La Roche Patent: DE820141 , 1951 ; Full Text Show Details Hoffmann-La Roche Patent: US2470108 , 1947 ; DRP/DRBP Org.Chem. Full Text Show Details Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

~%

phenindamine Structure

phenindamine

CAS#:82-88-2

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Literature: Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

~%

phenindamine Structure

phenindamine

CAS#:82-88-2

Learn More
Literature: Plati; Wenner Journal of Organic Chemistry, 1955 , vol. 20, p. 1412,1422

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  3

DownStream  0

 phenindamineBioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801
Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798
Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791
Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr
Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP
Name: Binding affinity towards human DRD2 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL5291781
Name: Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol...
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL5291777
Name: Binding affinity towards human DRD3 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(3) dopamine receptor
External Id: CHEMBL5291899
Name: Binding affinity towards human CNR1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Cannabinoid receptor 1
External Id: CHEMBL5291773
Name: Binding affinity towards human MC4R in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Melanocortin receptor 4
External Id: CHEMBL5291832
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Fenindamina
Phenindamine (INN)
Phenindamine [INN:BAN]
Phenindaminum
2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine
Nolahist
2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridin
Phenindiamine
Phenindamin
Phenindaminum [INN-Latin]
Fenindamina [INN-Spanish]
Thephorin
Phenindamine

 phenindamine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: Polar surface area (PSA) of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is 3.24000.
Q: What is the LogP of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: LogP of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is 3.85910.
Q: What is the CAS number of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: CAS number of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is 82-88-2.
Q: What are the uses of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: Main uses of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine: Phenindamine (Nu 1504) is an antihistamine[1].
Q: What are the upstream materials of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: Related upstream materials(CAS) of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine: 71839-14-0;60295-97-8;64-17-5.
Q: What is the molecular formula of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: Molecular formula of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is C19H19N.
Q: What is the English name of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: The English name of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine.
Q: What is the melting point of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: Melting point of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is 90-91°.
Q: What English synonyms does 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine have?
A: English synonyms of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine: Fenindamina, Phenindamine (INN), Phenindamine [INN:BAN], Phenindaminum, 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine, Nolahist, 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridin, Phenindiamine, Phenindamin, Phenindaminum [INN-Latin], Fenindamina [INN-Spanish], Thephorin, Phenindamine.
Q: What is the molecular weight of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine?
A: Molecular weight of 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine is 261.36100.

 phenindaminefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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