Name | 2-[2,6-diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenoxy]acetic acid |
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Description | KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle[1][2][3]. |
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Related Catalog | |
Target |
IC50: 4.5 μM (ThRα), 5.1 μM (ThRβ)[1] |
References |
Molecular Formula | C18H14I2O4 |
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Molecular Weight | 548.11000 |
Exact Mass | 547.89800 |
PSA | 59.67000 |
LogP | 5.00460 |