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90-50-6

90-50-6 structure
90-50-6 structure
  • Name: 3,4,5-Trimethoxycinnamic acid
  • Chemical Name: 3,4,5-trimethoxycinnamic acid
  • CAS Number: 90-50-6
  • Molecular Formula: C12H14O5
  • Molecular Weight: 238.237
  • Catalog: Flavors and spices Synthetic spice Aromatic cinnamic acid, esters and derivatives
  • Create Date: 2018-04-21 08:00:00
  • Modify Date: 2024-01-02 09:39:39
  • 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].

Name 3,4,5-trimethoxycinnamic acid
Synonyms 3,4,5-Trimethoxycinnamic
o-methylsinapicacid
3,4,5-Trimethoxy cinnamic acid
(2E)-3-(3,4,5-Trimethoxyphenyl)acrylic acid
2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)-
3,4,5-Trimethoxycinnamic acid
2-propenoic acid, 3-(3,4,5-trimethoxyphenyl)-
TRIMETHOXYCINNAMICACID
3,4,5-trimethoxy-cinnamicaci
5-TriMethoxycinnaMic acid
3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid
EINECS 201-999-8
3,4,5-Trimethoxyzimtsure
RARECHEM BK HC T328
MFCD00004388
Description 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
Related Catalog
Target

γ-subunit of GABAA receptor[2]

In Vitro 3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
In Vivo 3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1]. 3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
References

[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9.

[2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.

Density 1.2±0.1 g/cm3
Boiling Point 396.4±37.0 °C at 760 mmHg
Melting Point 125-127 °C(lit.)
Molecular Formula C12H14O5
Molecular Weight 238.237
Flash Point 151.5±20.0 °C
Exact Mass 238.084122
PSA 64.99000
LogP 2.00
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.560

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GE0722000
CHEMICAL NAME :
Cinnamic acid, 3,4,5-trimethoxy-
CAS REGISTRY NUMBER :
90-50-6
BEILSTEIN REFERENCE NO. :
1537834
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H14-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
422 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS GE0722000
HS Code 2916399090
HS Code 2916399090
Summary 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%