15503-86-3

15503-86-3 structure

Name: Isatidine
Chemical Name: isatidine
CAS Number: 15503-86-3
Molecular Formula: C₁₈H₂₅NO₇
Molecular Weight: 367.39400
Catalog: Research Areas Cancer
Create Date: 2017-08-02 15:31:30
Modify Date: 2024-01-12 16:56:29
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides[1][2].

Name	isatidine
Synonyms	Retrorsine N-oxide (3Z,5R,6S,14aR,14bR)-3-ethylidene-6-hydroxy-6-(hydroxymethyl)-5-methyl-3,4,5,6,9,11,13,14,14a,14b-decahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione 12-oxide

Description	Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vivo	Retrorsine N-oxide produces DNA adducts, the common biological biomarker of PA-induced liver tumor formation[1].
References	[1]. He X, et, al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991. [2]. Valese AC, et, al. Quantification of pyrrolizidine alkaloids in Senecio brasiliensis, beehive pollen, and honey by LC-MS/MS. J Environ Sci Health B. 2021;56(7):685-694.