21416-43-3
21416-43-3 structure
- Name: (S)-Willardiine
- Chemical Name: 3-(uracil-1-yl)-L-alanine
- CAS Number: 21416-43-3
- Molecular Formula: C7H9N3O4
- Molecular Weight: 199.16400
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2017-08-13 04:00:21
- Modify Date: 2024-01-11 18:58:58
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(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) [1]Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2].in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3].
| Name | 3-(uracil-1-yl)-L-alanine |
|---|---|
| Synonyms |
S(-)-α-AMINO-3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
S(−)-Willardiine S()-Willardiine (S)-Willardiine |
| Description | (S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.IC50 value: 44.8 uM(EC50) [1]Target: AMPA/kainate receptor agonistin vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2].in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3]. |
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| Related Catalog | |
| References |
| Density | 1.501 g/cm3 |
|---|---|
| Molecular Formula | C7H9N3O4 |
| Molecular Weight | 199.16400 |
| Exact Mass | 199.05900 |
| PSA | 118.18000 |
| Index of Refraction | 1.543 |
| HS Code | 2933599090 |
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| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |