63758-79-2
63758-79-2 structure
- Name: Indalpine
- Chemical Name: 3-(2-piperidin-4-ylethyl)-1H-indole
- CAS Number: 63758-79-2
- Molecular Formula: C15H20N2
- Molecular Weight: 228.33300
- Catalog: Signaling Pathways Neuronal Signaling Serotonin Transporter
- Create Date: 2018-06-14 09:53:07
- Modify Date: 2024-01-29 22:17:26
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Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].
| Name | 3-(2-piperidin-4-ylethyl)-1H-indole |
|---|---|
| Synonyms |
EINECS 264-445-4
Lipstene INDALPINE LM 5008 |
| Description | Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2]. |
|---|---|
| Related Catalog | |
| In Vivo | In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2]. |
| References |
| Density | 1.07 g/cm3 |
|---|---|
| Boiling Point | 405.1ºC at 760 mmHg |
| Molecular Formula | C15H20N2 |
| Molecular Weight | 228.33300 |
| Flash Point | 198.8ºC |
| Exact Mass | 228.16300 |
| PSA | 27.82000 |
| LogP | 3.42890 |
| Index of Refraction | 1.595 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| RIDADR | UN 3249 |
|---|---|
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |