Indalpine

Modify Date: 2025-08-25 21:54:50

Indalpine structure	Common Name	Indalpine
	CAS Number	63758-79-2	Molecular Weight	228.33300
	Density	1.07 g/cm3	Boiling Point	405.1ºC at 760 mmHg
	Molecular Formula	C₁₅H₂₀N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	198.8ºC

Use of Indalpine

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].

Name	3-(2-piperidin-4-ylethyl)-1H-indole
Synonym	More Synonyms

Description	Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vivo	In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2].
References	[1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104. [2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9.

Density	1.07 g/cm3
Boiling Point	405.1ºC at 760 mmHg
Molecular Formula	C₁₅H₂₀N₂
Molecular Weight	228.33300
Flash Point	198.8ºC
Exact Mass	228.16300
PSA	27.82000
LogP	3.42890
Index of Refraction	1.595
InChIKey	SADQVAVFGNTEOD-UHFFFAOYSA-N
SMILES	c1ccc2c(CCC3CCNCC3)c[nH]c2c1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1303800

CHEMICAL NAME :: 1H-Indole, 3-(2-(4-piperidinyl)ethyl)-

CAS REGISTRY NUMBER :: 63758-79-2

BEILSTEIN REFERENCE NO. :: 0612584

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H20-N2

MOLECULAR WEIGHT :: 228.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

3-(2-(Pyridin-4...

CAS#:16571-49-6

~74%

Indalpine

CAS#:63758-79-2

Literature: Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310

4-Vinylpyridine

CAS#:100-43-6

Indalpine

CAS#:63758-79-2

Literature: Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310

Indole

CAS#:120-72-9

Indalpine

CAS#:63758-79-2

Literature: Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310

Precursor 2
CAS#:100-43-6 4-Vinylpyridine CAS#:120-72-9 Indole
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Compound was tested for potentiation of 5-HTP in mouse after subcutaneous administrat...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL736088

Name: Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell...
Source: ChEMBL
Target: Bile salt export pump
External Id: CHEMBL4017550

Name: Choleostatic liver toxicity, either proven histopathologically or where the ratio of ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137727

Name: Severe hepatitis, defined as possibly life-threatening liver failure or through clini...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137728

Name: Chronic liver disease either proven histopathologically, or through a chonic elevatio...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137729

Name: Cirrhosis, proven histopathologically. Value is number of references indexed. [column...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137730

Name: Granulomatous liver disease, proven histopathologically. Value is number of reference...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3137731

Name: Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive dise...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137732

Name: Steatosis, proven histopathologically. Value is number of references indexed. [column...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137733

Name: In vivo inhibition of uptake of 5-HT in human platelets
Source: ChEMBL
Target: Sodium-dependent serotonin transporter
External Id: CHEMBL702340

Total 33, Current Page 1 of 4

EINECS 264-445-4

Lipstene

INDALPINE

LM 5008

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ACUTE TOXICITY DATA

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.