Indalpine

Modify Date: 2026-08-06 18:36:21

Indalpine structure	Common Name	Indalpine
	CAS Number	63758-79-2	Molecular Weight	228.33300
	Density	1.07 g/cm3	Boiling Point	405.1ºC at 760 mmHg
	Molecular Formula	C₁₅H₂₀N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	198.8ºC

Use of Indalpine

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].

Summary: Indalpine, also known as 3-(2-piperidin-4-ylethyl)-1H-indole, has a CAS number of 63758-79-2, with a molecular formula of C15H20N2 and a molecular weight of 228.33300. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	3-(2-piperidin-4-ylethyl)-1H-indole
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vivo	In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2].
References	[1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104. [2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.07 g/cm3
Boiling Point	405.1ºC at 760 mmHg
Molecular Formula	C₁₅H₂₀N₂
Molecular Weight	228.33300
Flash Point	198.8ºC
Exact Mass	228.16300
PSA	27.82000
LogP	3.42890
Index of Refraction	1.595
InChIKey	SADQVAVFGNTEOD-UHFFFAOYSA-N
SMILES	c1ccc2c(CCC3CCNCC3)c[nH]c2c1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM1303800

CHEMICAL NAME :: 1H-Indole, 3-(2-(4-piperidinyl)ethyl)-

CAS REGISTRY NUMBER :: 63758-79-2

BEILSTEIN REFERENCE NO. :: 0612584

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H20-N2

MOLECULAR WEIGHT :: 228.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 500 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

3-(2-(Pyridin-4...

CAS#:16571-49-6

~74%

Indalpine

CAS#:63758-79-2

Learn More

Literature: Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310

4-Vinylpyridine

CAS#:100-43-6

Indalpine

CAS#:63758-79-2

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Literature: Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310

Indole

CAS#:120-72-9

Indalpine

CAS#:63758-79-2

Learn More

Literature: Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 2
CAS#:100-43-6 4-Vinylpyridine CAS#:120-72-9 Indole
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Compound was tested for potentiation of 5-HTP in mouse after subcutaneous administrat...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL736088

Name: Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell...
Source: ChEMBL
Target: Bile salt export pump
External Id: CHEMBL4017550

Name: Choleostatic liver toxicity, either proven histopathologically or where the ratio of ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137727

Name: Severe hepatitis, defined as possibly life-threatening liver failure or through clini...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137728

Name: Chronic liver disease either proven histopathologically, or through a chonic elevatio...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137729

Name: Cirrhosis, proven histopathologically. Value is number of references indexed. [column...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137730

Name: Granulomatous liver disease, proven histopathologically. Value is number of reference...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3137731

Name: Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive dise...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137732

Name: Steatosis, proven histopathologically. Value is number of references indexed. [column...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3137733

Name: In vivo inhibition of uptake of 5-HT in human platelets
Source: ChEMBL
Target: Sodium-dependent serotonin transporter
External Id: CHEMBL702340

Total 33, Current Page 1 of 4

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 264-445-4

Lipstene

INDALPINE

LM 5008

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: The English name of 3-(2-piperidin-4-ylethyl)-1H-indole is 3-(2-piperidin-4-ylethyl)-1H-indole.

Q: What is the CAS number of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: CAS number of 3-(2-piperidin-4-ylethyl)-1H-indole is 63758-79-2.

Q: What English synonyms does 3-(2-piperidin-4-ylethyl)-1H-indole have?

A: English synonyms of 3-(2-piperidin-4-ylethyl)-1H-indole: EINECS 264-445-4, Lipstene, INDALPINE, LM 5008.

Q: What is the molecular weight of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: Molecular weight of 3-(2-piperidin-4-ylethyl)-1H-indole is 228.33300.

Q: What is the molecular formula of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: Molecular formula of 3-(2-piperidin-4-ylethyl)-1H-indole is C15H20N2.

Q: What is the boiling point of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: Boiling point of 3-(2-piperidin-4-ylethyl)-1H-indole is 405.1ºC at 760 mmHg.

Q: What are the uses of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: Main uses of 3-(2-piperidin-4-ylethyl)-1H-indole: Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].

Q: What is the InChIKey of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: InChIKey of 3-(2-piperidin-4-ylethyl)-1H-indole is SADQVAVFGNTEOD-UHFFFAOYSA-N.

Q: What are the upstream materials of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: Related upstream materials(CAS) of 3-(2-piperidin-4-ylethyl)-1H-indole: 100-43-6;120-72-9.

Q: What is the SMILES notation of 3-(2-piperidin-4-ylethyl)-1H-indole?

A: SMILES notation of 3-(2-piperidin-4-ylethyl)-1H-indole is c1ccc2c(CCC3CCNCC3)c[nH]c2c1.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Indalpine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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