Shanghai Nianxing Industrial Co., Ltd
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Product Name: Kirromycin
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Kirromycin
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Purity: 98.0%
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Contact: Tony Cao
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50935-71-2

50935-71-2 structure

50935-71-2 structure

Name: Kirromycin
Chemical Name: Kirromycin
CAS Number: 50935-71-2
Molecular Formula: C₄₃H₆₀N₂O₁₂
Molecular Weight: 796.94300
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-20 03:50:27
Modify Date: 2024-01-02 11:35:57
Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces ramocissimus. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome[1][2].

Name	Kirromycin
Synonyms	antibiotic myc-8003

Description	Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces ramocissimus. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. H Wolf, et al. Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4910-4. [2]. Lian N Olsthoorn-Tieleman, et al. Elongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors. J Bacteriol. 2007 May;189(9):3581-90.

Density	1.279g/cm3
Boiling Point	936ºC at 760 mmHg
Molecular Formula	C₄₃H₆₀N₂O₁₂
Molecular Weight	796.94300
Flash Point	519.9ºC
Exact Mass	796.41500
PSA	228.10000
LogP	3.46570
Index of Refraction	1.621

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QA2805000

CHEMICAL NAME :: Mocimycin

CAS REGISTRY NUMBER :: 50935-71-2

LAST UPDATED :: 199103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C43-H60-N2-O12

MOLECULAR WEIGHT :: 797.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,109,1981

RIDADR	NONH for all modes of transport